CELL-PROLIFERATION IN HUMAN CORONARY-ARTERIES
CELL-PROLIFERATION IN HUMAN CORONARY-ARTERIES
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DOI：
10.1073/pnas.87.12.4600
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发表时间：
1990-06-01
影响因子：
11.1
通讯作者：
SCHWARTZ, SM
中科院分区：
文献类型：
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作者：
GORDON, D;REIDY, MA;SCHWARTZ, SM
尽管缺乏细胞增殖的直接证据，但在人类动脉粥样硬化病变中，平滑肌细胞的增殖被认为在斑块的个体发生中起着核心作用。我们在人体动脉和冠状动脉粥样硬化斑块的组织切片上使用了细胞周期相关蛋白的抗体。通过免疫化学试剂对平滑肌、单核巨噬细胞和其他血细胞进行特定的细胞类型鉴定。血管平滑肌细胞增殖率低。巨噬细胞的增殖率与平滑肌的增殖率相当。对于本研究中使用的试剂，不能将额外的复制细胞定义为属于特定的细胞类型。这些发现表明，晚期斑块中的平滑肌复制是迟缓的，并增加了白细胞增殖的可能性。
Despite the lack of direct evidence for cell multiplication, proliferation of smooth muscle cells in human atherosclerotic lesions has been assumed to play a central role in ontogeny of the plaque. We used antibodies to cell cycle-related proteins on tissue sections of human arteries and coronary atherosclerotic plaques. Specific cell types were identified by immunochemical reagents for smooth muscle, monocyte-macrophages, and other blood cells. Low rates of smooth muscle cell proliferation were observed. Macrophages were also observed with rates of proliferation comparable to that of the smooth muscle. Additional replicating cells could not be defined as belonging to specific cell types with the reagents used in this study. These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.