The microenvironment-a general hypothesis on the homeostatic function of extracellular vesicles.
The microenvironment-a general hypothesis on the homeostatic function of extracellular vesicles.
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DOI：
10.1096/fba.2021-00155
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发表时间：
2022-05
影响因子：
2.7
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中科院分区：
文献类型：
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细胞外囊泡（EV），外泌体和微囊泡，是一个新兴的生物和生物医学研究领域，可能会改变我们对植物和动物细胞通讯的理解，同时为疾病诊断和治疗方法的发展带来巨大希望。然而，挑战仍然是发展一个关于EV在跨王国的生理稳态和病理生物学中的作用的一般假设。虽然它们可以系统地发挥作用，但电动汽车通常被视为在微环境中局部运行。该微环境被构建为由通过EV交换、EV信号传导、EV接种和EV处置彼此相互作用的细胞组成的微单元的集合。我们认为，微单位是组织水平上更大基质的一部分，与周围环境（包括其他终末器官系统）共同沟通。在这里，我们提供了一个工作模型，包括EV功能的各个方面的背景下，多细胞生物体的细胞生物学和生理学。
Extracellular vesicles (EVs), exosomes and microvesicles, is a burgeoning field of biological and biomedical research that may change our understanding of cell communication in plants and animals while holding great promise for the diagnosis of disease and the development of therapeutics. However, the challenge remains to develop a general hypothesis about the role of EVs in physiological homeostasis and pathobiology across kingdoms. While they can act systemically, EVs are often seen to operate locally within a microenvironment. This microenvironment is built as a collection of microunits comprised of cells that interact with each other via EV exchange, EV signaling, EV seeding, and EV disposal. We propose that microunits are part of a larger matrix at the tissue level that collectively communicates with the surrounding environment, including other end‐organ systems. Herein, we offer a working model that encompasses the various facets of EV function in the context of the cell biology and physiology of multicellular organisms.