EFFECT OF HYPERTHERMIA ON VASCULAR FUNCTION IN NORMAL AND NEOPLASTIC TISSUES *
EFFECT OF HYPERTHERMIA ON VASCULAR FUNCTION IN NORMAL AND NEOPLASTIC TISSUES *
复制标题
热疗对正常和肿瘤组织血管功能的影响*
DOI：
10.1111/j.1749-6632.1980.tb50735.x
复制
发表时间：
1980
影响因子：
5.2
通讯作者：
S. Levitt
中科院分区：
文献类型：
--
作者：
C. Song;Man‐Sik Kang;J. Rhee;S. Levitt
最近的一些实验室研究表明，热疗本身不仅对恶性细胞具有细胞毒性，而且还增强放射线和某些化疗药物的作用。'-'抗放射缺氧细胞的存在被认为是放射治疗控制肿瘤的限制因素。有趣的是，肿瘤中这些抗辐射的缺氧细胞至少与含氧细胞一样对热敏感。'-'o基于这些令人鼓舞的结果，许多医疗中心已经在进行将热疗作为主要治疗方式或作为放射治疗的辅助治疗恶性肿瘤的临床试验^。“”^显然，只有当热疗对肿瘤优先有效时，才能预期热疗治疗肿瘤的临床益处。迹象表明，体外肿瘤细胞并不一定比体外正常细胞对热更敏感。然而，许多报道表明，与体外肿瘤细胞不同，体内恶性组织比邻近正常组织更容易受热影响。'-'*''-''体内恶性细胞的高酸度、低p02和营养状态差，被认为是热疗对肿瘤优先作用的可能原因。'*'*'6 除了上述之外，差异肿瘤和正常组织中血流的变化可能在肿瘤和正常组织对高热的差异反应中发挥重要作用。有人提出，由于血液 ROW 缓慢，热疗过程中热量无法有效地从肿瘤消散。'^-''*'^ 然而，这种可能性尚未得到充分研究。在本报告中，我们总结了我们在热疗期间实验肿瘤和大鼠正常组织中的血管内容积、血管通透性和血流速率的工作。m-2'
A number of recent laboratory investigations demonstrated that hyperthermia is not only cytotoxic to malignant cells by itself, but it also potentiates the effect of radiation and certain chemotherapeutic drugs.'-' The presence of radioresistant hypoxic cells is believed to be the limiting factor for the control of tumor by radiotherapy. Interestingly, these radioresistant hypoxic cells in tumors are a t least equally as heat-sensitive as the oxic cells.'-'o Based on these encouraging results, clinical trials of hyperthermia as a primary modality or as an adjuvant to radiotherapy for the treatment of malignant tumors are already in progress in many medical center^."“^ Obviously, clinical benefit of hyperthermia for the cure.of tumors can be expected only if this modality is preferentially effective on tumors. Indications are that tumor cells in vitro are not necessarily more sensitive to heat than normal cells in vitro.Is A number of reports, however, suggested that, unlike tumor cells in vitro, malignant tissues in vivo are more vulnerable to heat than adjacent normal tissues.'-'*''-'' The high acidity, low p02, and poor nutritional state of malignant cells in vivo have been suggested to be the probable causes of the preferential effect of hyperthermia on tumors.'*'*'6 In addition to the above, the difference in blood flow in tumors and normal tissues may play an important role in the differential response of tumors and normal tissues to hyperthermia. It has been suggested that heat is not effectively dissipated from the tumor during hyperthermia because of sluggish blood ROW.'^-''*'^ This possibility, however, has not yet been fully investigated. In the present report we summarize our work on the intravascular volume, vascular permeability, and blood flow rate in an experimental tumor and in normal tissues of rats during hyperthermia.m-2'