Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles
Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles
复制标题
DOI：
10.2340/00015555-2949
复制
发表时间：
2018-07-01
影响因子：
3.6
通讯作者：
Kishimoto, Jiro
中科院分区：
文献类型：
--
作者：
Niiyama, Shiro;Ishimatsu-Tsuji, Yumiko;Kishimoto, Jiro
构成毛囊真皮乳头的细胞可能来源于真皮鞘，其球周成分是真皮鞘杯。所述真皮鞘杯被认为包括真皮乳头的祖细胞并具有毛诱导电位；然而，它还没有很好地表征。本研究研究了完整真皮鞘杯的基因表达谱，确定了真皮鞘杯的特征基因，包括细胞外基质成分和骨形态发生蛋白结合分子，以及作为上游调节因子的转化生长因子β 1。其中，骨形态发生蛋白拮抗剂成员gremilin-2通过原位杂交发现对真皮鞘杯具有高度特异性，这意味着gremilin-2是维持真皮鞘杯特性的关键分子。
Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it has not yet been well characterized. This study investigated the gene expression profile of the intact dermal sheath cup, and identified dermal sheath cup signature genes, including extracellular matrix components and bone morphogenetic protein-binding molecules, as well as transforming frowth factor beta 1 as an upstream regulator. Among these, gremilin-2, a member of the bone morphogenetic protein antagonists, was found by in situ hybridization to be highly specific to the dermal sheath cup, implying that gremlin-2 is a key molecule contributing to maintenance of the properties of the dermal sheath cup.