Efficacy of Probiotics in Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Controlled Trials
Efficacy of Probiotics in Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Controlled Trials
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DOI：
10.1007/s10350-008-9335-z
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发表时间：
2008-12-01
影响因子：
3.9
通讯作者：
Abdollahi, Mohammad
中科院分区：
文献类型：
--
作者：
Nikfar, Shekoufeh;Rahimi, Roja;Abdollahi, Mohammad
目的：本研究旨在评价益生菌是否能改善肠易激综合征患者的症状。方法：检索PubMed、Embase、Scope us、Web of Science和Cochrane Central Register of Control Trials，研究益生菌在肠易激综合征治疗中的疗效。临床改善是令人感兴趣的关键结果。检索1966年至2007年9月期间的数据。结果：8项随机、安慰剂对照的临床试验符合我们的标准并纳入分析。临床改善结果的8个试验合并后的显著相对危险度为1.2 2(95%可信区间为1.0 7~1.4；P=0.0042)。结论：益生菌可改善肠易激综合征的症状，可作为标准治疗的补充。
PURPOSE: This study was designed to evaluate whether probiotics improve symptoms in patients with irritable bowel syndrome.METHODS: PubMed, Embase, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched for studies that investigated the efficacy of probiotics in the management of irritable bowel syndrome. Clinical improvement was the key outcome of interest. Data were searched within the time period of 1966 through September 2007.RESULTS: Eight randomized, placebo-controlled, clinical trials met our criteria and were included in the analysis. Pooling of eight trials for the outcome of clinical improvement yielded a significant relative risk of 1.22 (95 percent confidence interval, 1.07-1.4; P=0.0042).CONCLUSIONS: Probiotics may improve symptoms of irritable bowel syndrome and can be used as supplement to standard therapy.