Type 2 diabetes in South Asians: similarities and differences with white Caucasian and other populations
Type 2 diabetes in South Asians: similarities and differences with white Caucasian and other populations
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DOI：
10.1111/j.1749-6632.2012.06838.x
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Mohan, V.
中科院分区：
文献类型：
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作者：
Gujral, Unjali P.;Pradeepa, R.;Mohan, V.
2型糖尿病(T2 DM)是导致发病率和死亡率的主要原因之一。虽然所有民族都受到影响，但在南亚人中，无论是在本国还是在国外，T2 DM的患病率都非常高，而且还在继续快速上升。与生俱来的生物易感性加上身体活动、饮食和其他生活方式行为的快速变化，是推动这一人群疾病负担增加的原因之一。这一问题的范围很广，需要在个人和人口层面调查易感性增加的原因，并在个人和人口层面开展具有侵略性、文化敏感性和很早开始的预防工作。在这篇综述中，我们概述了与高加索人和其他民族相比，使南亚人患T2 DM风险增加的生物和环境因素。
Type 2 diabetes mellitus (T2DM) is one of the leading causes of morbidity and mortality. While all ethnic groups are affected, the prevalence of T2DM in South Asians, both in their home countries and abroad, is extremely high and is continuing to rise rapidly. Innate biological susceptibilities coupled with rapid changes in physical activity, diet, and other lifestyle behaviors are contributing factors propelling the increased burden of disease in this population. The large scope of this problem calls for investigations into the cause of increased susceptibility and preventative efforts at both the individual and population level that are aggressive, culturally sensitive, and start early. In this review, we outline the biological and environmental factors that place South Asians at elevated risk for T2DM, compared with Caucasian and other ethnic groups.