Immunohistological localization and possible functions of adrenomedullin.
Immunohistological localization and possible functions of adrenomedullin.
复制标题
肾上腺髓质素的免疫组织学定位和可能的功能。
作者：
K. Marutsuka;K. Hatakeyama;Yuichiro Sato;A. Yamashita;A. Sumiyoshi;Y. Asada
在这篇简短的综述中，我们描述了肾上腺髓质素（AM）免疫反应细胞在人体组织中的分布及其相关的生物学特性，重点是血液凝固和粘膜防御系统。AM广泛分布于人体组织中，尤其是心血管和内分泌组织。在血管内，AM已在血管平滑肌细胞（SMCs）和内皮细胞（ECs）中被免疫组织化学检测到。在动脉粥样硬化病变中，这种肽不仅存在于这些细胞中，也存在于巨噬细胞中，并且在位于动脉粥样硬化斑块肩部病变的巨噬细胞中检测到最强烈的AM免疫反应，这些巨噬细胞被认为是容易破裂的区域。AM抑制组织因子的产生，并增加主动脉内皮细胞组织因子通路抑制剂的产生和释放。AM也诱导抗凝血酶和尿激酶型纤溶酶原激活剂从内皮细胞释放。综上所述，肽的这些抗血栓特性有望在维持血液循环中发挥重要作用。此外，在胃肠道、呼吸系统和生殖系统的粘膜和腺上皮中观察到AM的免疫反应性。AM和肾上腺髓质n端20肽（PAMP）对大肠杆菌具有较强的抗菌活性。此外，AM也存在于听觉系统中。这些证据表明AM及其相关肽不仅在哺乳动物血管舒张中发挥作用，而且在哺乳动物中表现出多种生物活性。
In this short review, we describe the distribution of adrenomedullin (AM)-immunoreactive cells in human tissues and their related biological properties, focusing on the blood coagulation and mucosal defense systems. AM is widely distributed in human tissues, especially in cardiovascular and endocrine tissues. Within vessels, AM has been immunohistochemically detected in vascular smooth muscle cells (SMCs) and endothelial cells (ECs). In atherosclerotic lesions, the peptide is present not only in these cells, but also in macrophages, and the most intense AM immunoreactivity is detected in macrophages located in shoulder lesions of atheromatous plaque, which are considered to be rupture-prone regions. AM inhibits tissue factor production, and augments the production and release of tissue factor pathway inhibitor from aortic ECs. AM also induces the release of antithrombin and urokinase-type plasminogen activator from ECs. Taken together, these antithrombotic properties of the peptide are expected to play an important role in the maintenance of blood circulation. Furthermore, AM immunoreactivity is observed in mucosal and glandular epithelia of the gastrointestinal, respiratory and reproductive systems. AM and the proadrenomedullin N-terminal 20 peptide (PAMP) show strong antibacterial activity against Escherichia coli. In addition, AM is also present in the auditory system. These lines of evidence suggest that AM and its related peptides not only play a role in vasodilatation, but also exhibit multiple biological activities in mammals.
DOI：
10.1073/pnas.98.2.615
发表时间：
2001-01
影响因子：
11.1
作者：
K. Caron;O. Smithies
通讯作者：
K. Caron;O. Smithies
球囊导管损伤后内膜平滑肌细胞增殖。
DOI：
--
发表时间：
1992
期刊：
The American journal of pathology
影响因子：
--
作者：
Olson,NE;Chao,S;Lindner,V;Reidy,MA
通讯作者：
Reidy,MA