Fluoxetine treatment decreases territorial aggression in a coral reef fish.
Fluoxetine treatment decreases territorial aggression in a coral reef fish.
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氟西汀治疗可减少珊瑚礁鱼的领地攻击性。
DOI：
10.1016/s0031-9384(03)00211-7
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发表时间：
2003
影响因子：
2.9
通讯作者：
Godwin,John
中科院分区：
文献类型：
--
作者：
Perreault,HeidiAN;Semsar,Katharine;Godwin,John
血清素是调节许多动物社交互动的重要神经递质。对包括鱼类在内的许多脊椎动物物种的相关研究表明，攻击性较强的雄性比攻击性较小的雄性具有较低的相对血清素活性。我们使用氟西汀（一种选择性血清素再摄取抑制剂）通过实验增强领地珊瑚礁鱼的血清素神经传递，并测试这种神经递质在介导攻击行为和优势相互作用中的作用。蓝头濑鱼（Thalassoma bifasciatum）有一个复杂的社会系统，在这个系统中，大型雄性会积极地保护产卵领地免受入侵者的侵害。在单独的实验中，我们使用居民-入侵者设计测试了慢性和急性氟西汀治疗对攻击行为的影响。在一项实验室实验中，连续两周每天腹腔注射氟西汀（6 μg/g bw）的雄性动物比生理盐水处理的对照组表现出更少的入侵者追逐。在入侵者试验之前，长期接受氟西汀治疗的雄性动物的活动水平也低于盐水对照组。然而，活动与个体水平上的追逐无关，这表明氟西汀治疗的雄性表现出较低的攻击性不仅仅是由于行为表现的普遍减少。一项实地研究将雄性在不同日期腹腔注射氟西汀（10 μg/g bw）或生理盐水，暴露在有限的领地入侵者之下。急性氟西汀治疗后的攻击性追逐频率明显低于注射生理盐水后的频率。这项研究在受控实验室测试环境和动物自然栖息地中通过实验支持了血清素与鱼类攻击行为之间的联系。
Serotonin is an important neurotransmitter in the regulation of social interactions in many animals. Correlative studies in numerous vertebrate species, including fishes, indicate that aggressive males have lower relative serotonergic activity than less aggressive males. We used fluoxetine, a selective serotonin reuptake inhibitor, to experimentally enhance serotonergic neurotransmission in a territorial coral reef fish and test the role of this neurotransmitter in mediating aggressive behavior and dominance interactions. The bluehead wrasse, Thalassoma bifasciatum, has a complex social system in which large males aggressively defend spawning territories from intruders. In separate experiments, we tested the effects of chronic and acute fluoxetine treatments on aggressive behavior using a resident–intruder design. In a laboratory experiment, males treated daily with intraperitoneal fluoxetine injections for 2 weeks (6 μg/g bw) displayed fewer intruder chases than saline-treated controls. Chronically fluoxetine-treated males also showed lower levels of activity than saline controls prior to intruder trials. However, activity was not correlated with chases on an individual level, indicating the lower aggression displayed by fluoxetine-treated males was not due solely to general reductions in behavioral display. A field study exposed males to a confined territorial intruder following single intraperitoneal injections of fluoxetine (10 μg/g bw) or saline given to the same individual on different days. The frequency of aggressive chases following acute fluoxetine treatment was significantly lower than that following saline injections. This study experimentally supports the link between serotonin and aggressive behavior in fishes in both a controlled laboratory testing environment and the animal's natural habitat.