Inflammasomes and anti-viral immunity.
Inflammasomes and anti-viral immunity.
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炎症小体和抗病毒免疫。
DOI:
10.1007/s10875-010-9431-4
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发表时间:
2010
影响因子:
9.1
通讯作者:
Fitzgerald,KatherineA
中科院分区:
文献类型:
--
作者:
Rathinam,VijayAK;Fitzgerald,KatherineA
Type I Interferons are the hallmark cytokines deployed during infection to combat invading viruses. However, inflammatory cytokines such as Interleukin (IL)-1β and IL-18 also play important roles in anti-viral defenses. The activity of IL-1β and IL18 are regulated at the level of expression, processing, and secretion. Several classes of innate immune receptors control the expression of these cytokines, which must then be proteolytically processed via caspase-1. In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity.
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