Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress
Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress
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DOI：
10.1016/j.neulet.2005.01.083
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发表时间：
2005-06-24
影响因子：
2.5
通讯作者：
Vieau, D
中科院分区：
文献类型：
--
作者：
Laborie, C;Dutriez-Casteloot, I;Vieau, D
我们以前已经表明，产前吗啡暴露抑制下丘脑-垂体-肾上腺（HPA）轴和改变下丘脑5-羟色胺的代谢在出生后早期的大鼠和成年雄性大鼠在静息条件下诱导慢性交感肾上腺功能亢进。在这项研究中，我们研究了产前吗啡暴露对3个月大的雄性大鼠的交感肾上腺和HPA轴的急性乙醚吸入应激反应和海马和下丘脑5-羟色胺（5 HT）和5-羟基吲哚乙酸（5 HIAA）浓度的影响。在静息状态下和乙醚暴露后，两组间肾上腺皮质激素（ACTH）和皮质酮（B）的血浆水平无差异。乙醚吸入增加肾上腺酪氨酸羟化酶（TH）和苯乙醇胺N-甲基转移酶（PNMT）mRNA的表达，以及肾上腺素（E）的浓度在对照组大鼠，但在产前吗啡暴露（PM）的动物。在基础条件下，PM动物下丘脑5 HT和5 HIAA浓度增加。与对照组相比，PM大鼠表现出，在应激反应，增加水平的5 HT和5 HIAA在下丘脑和海马。总之，产前吗啡暴露产生长期持久的改变，在脑5-羟色胺传输和交感肾上腺反应急性全身应激。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
We have previously shown that prenatal morphine exposure inhibited the hypothalamo-pituitary-adrenal (HPA) axis and altered the hypothalamic metabolism of serotonin during the early postnatal period in the rat and induced a chronic sympathoadrenal hyperactivity under resting conditions in adult male rats. In this study, we examined the effects of prenatal morphine exposure on the responsiveness to an acute ether inhalation stress of the sympathoadrenal and HPA axis and the hippocampal and hypothalamic concentrations of serotonin (5HT) and 5-hydroxylindoleacetic acid (5HIAA) in 3-month-old male rats. The plasma levels of adrenocorticopic hormone (ACTH) and corticosterone (B) did not differ between the two groups both under resting conditions and after ether exposure. Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals. Under basal conditions, hypothalamic concentrations of 5HT and 5HIAA increased in PM animals. In contrast to control animals, PM rats showed, in response to stress, an increased level of 5HT and 5HIAA in both the hypothalamus and in the hippocampus. In conclusion, prenatal morphine exposure produces long-lasting alterations in brain serotonin transmission and in the sympathoadrenal responsiveness to an acute systemic stress. (c) 2005 Elsevier Ireland Ltd. All rights reserved.