RESPONSE PLASTICITY OF PAIN EVOKED REACTIONS IN MAN
RESPONSE PLASTICITY OF PAIN EVOKED REACTIONS IN MAN
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DOI：
10.1016/0031-9384(82)90111-1
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发表时间：
1982-01-01
影响因子：
2.9
通讯作者：
SCHAREIN, E
中科院分区：
文献类型：
--
作者：
BROMM, B;SCHAREIN, E
对11名21-31岁的男性志愿者进行了痛觉估计（E）、诱发脑电位（EP）、眼电图（EOG）、退缩反射活动肌电图（EMG）和皮肤电传导反应（SCR）的测定。对指尖施加恒定电流刺激（20 ms; 2、3、5、10 mA）（平均疼痛阈值为5.1 mA）。刺激间隔（20-40 s）和刺激强度以准随机顺序提供，每个强度出现40次/会话。重复四次治疗，每次治疗之间间隔2天。随机刺激强度，功率谱密度函数的prestimulus脑电图表示一个稳定的非特异性唤醒水平之间和会话内。在这些条件下，没有显着的反应可塑性，发现E和EP，而不是在prepain或疼痛范围，也没有之间或内的会议。相反，EOG、EMG和SCR的振幅随着时间的推移而急剧下降，尤其是在第1和第2次会话之间以及每个会话中的前10个和后10个等强度刺激之间。EP和E在重复会话中保持高度相关。EOG-EP污染可以排除，因为它们对重复刺激的时间过程不同。
Pain estimation (E), evoked cerebral potential (EP), electrooculogram (EOG), electromyogram of withdrawal reflex activity (EMG) and skin conductance reaction (SCR) were measured in response to electrical skin stimuli in 11 male volunteers (age 21-31 yr). Constant current stimuli (20 ms; 2, 3, 5, 10 mA) were applied to a fingertip (averaged pain threshold at 5.1 mA). Interstimulus intervals (20-40 s) and stimulus intensities were delivered in quasirandomized order, each intensity appearing 40 times/session. Four sessions were repeated with intervals of 2 days between sessions. With randomized stimulus intensities, power spectral density functions of the prestimulus EEG indicated a stable non-specific arousal level between and within sessions. Under these conditions no significant response plasticity was found for E and EP, not in the prepain or the pain range and also not between or within sessions. In contrast, the amplitudes of EOG, EMG and SCR decreased drastically with time, especially between the 1st and 2nd session and between the first 10 and second 10 stimuli of equal intensity in each session. EP and E remained highly correlated in repeated sessions. A EOG-EP contamination could be ruled out because of their different time course to repeated stimuli.