Drug self-templated synthesis of ibuprofen/mesoporous silica for sustained release
Drug self-templated synthesis of ibuprofen/mesoporous silica for sustained release
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DOI：
10.1002/ejic.200501035
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发表时间：
2006-10-02
影响因子：
2.3
通讯作者：
Qiu, Shilun
中科院分区：
文献类型：
--
作者：
Qu, Fengyu;Zhu, Guangshan;Qiu, Shilun
采用药物自模板一步共缩合法合成了IRFs/介孔氧化硅复合材料。在中性水溶液体系中，将药物模板I3 O 4、3-氨丙基三乙氧基硅烷（APTES）和正硅酸乙酯（TEOS）共模板自组装到I3 O 4/介孔氧化硅中。该药物/介孔二氧化硅通过粉末XRD衍射、FTIR光谱、N-2吸附/脱附、TEM、Si-29/ MAS和C-13/MAS NMR光谱进行表征。ICPs/介孔二氧化硅系统给出了良好的持续释放曲线。
The synthesis of Ibuprofen/mesoporous silica has been achieved by a drug self-templated one-step co-condensation process. The drug template of Ibuprofen, a co-template of 3-aminopropyltriethoxysilane (APTES), and tetraethoxysiliane (TEOS) were self-assembled into Ibuprofen/mesoporous silica in a neutral aqueous reaction system. This drug/mesoporous silica was characterized by powder XRD diffraction, FTIR spectroscopy, N-2 adsorption/desorption, TEM, and Si-29/ MAS and C-13/MAS NMR spectroscopy. The Ibuprofen/mesoporous silica system gives a well-sustained release profile.