Gender difference in rheologic properties of blood and risk of cardiovascular diseases.
Gender difference in rheologic properties of blood and risk of cardiovascular diseases.
复制标题
血液流变特性和心血管疾病风险的性别差异。
DOI：
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发表时间：
1999
影响因子：
2.1
通讯作者：
H. Borovetz
中科院分区：
文献类型：
--
作者：
M. Kameneva;M. Watach;H. Borovetz
根据官方统计数据，绝经前妇女和年龄相当的男子在心脏病，特别是心肌梗塞的发病率和死亡率方面存在显著差异。关于这一现象的性质，有几种猜测，既有支持的证据，也有反驳的证据。我们的假设是，由于有规律的生理性出血，绝经前妇女的血液流变学特性上级男性，并使这些妇女患心血管疾病的风险低于任何年龄组的男性。我们认为，血液流变学特性的这种差异是由于红细胞（RBC）浓度降低，以及女性血液中年轻RBC的数量增加而老年RBC的数量减少。我们研究了47名绝经前妇女和50名年龄匹配的男性血液的机械性能。与女性血液相比，男性血液具有更高的粘度和红细胞聚集性以及更低的红细胞变形性。氧气输送指数，计算为红细胞压积与血液粘度的比值，发现男性血液中显着较低。氧气输送沿着减少，同时红细胞聚集增加和红细胞变形能力降低，可能导致心血管疾病发生的风险增加。定期献血可以降低血细胞比容和血液粘度，改善血液的流变学特性，并增加男性的氧气输送。
According to official statistical data there is a significant difference between pre-menopausal women and age-matched men in morbidity and mortality from cardiac diseases and especially from myocardial infarction. There are several speculations regarding the nature of this phenomenon which have both supporting and refuting evidence. Our hypothesis was that due to regular physiologic bleeding, rheological properties of blood of pre-menopausal women are superior to those of men, and place such women at a lower risk of cardiovascular diseases than men in any age group. We believe that this difference in hemorheological properties is due to the reduced concentration of red blood cells (RBCs) and due to greater population of younger and less population of older RBCs in female blood. We studied mechanical properties of blood from 47 pre-menopausal women and 50 age-matched men. Compared to female blood, male blood had higher viscosity and RBC aggregation and lower RBC deformability. Oxygen Delivery Index, calculated as a ratio of hematocrit to blood viscosity, was found to be significantly lower in male blood. Decreased oxygen delivery along with increased RBC aggregation and decreased RBC deformability may contribute to the higher risk for the development of cardiovascular diseases. Regular blood donation may reduce hematocrit and blood viscosity, improve rheological properties of blood, and increase oxygen delivery in men.
衰老红细胞的流变特性：随着红细胞年龄的增长，表面积和体积减少。
影响因子：
20.3
作者：
Waugh,RE;Narla,M;Jackson,CW;Mueller,TJ;Suzuki,T;Dale,GL
通讯作者：
Dale,GL
热处理改变红细胞膜粘弹性：对细胞变形性和悬浮液粘度的影响。
影响因子：
1.1
作者：
Nash,GB;Meiselman,HJ
通讯作者：
Meiselman,HJ
DOI：
10.1073/pnas.91.11.5212
发表时间：
1994-05-24
影响因子：
11.1
作者：
WEINER, CP;LIZASOAIN, I;MONCADA, S
通讯作者：
MONCADA, S