LYMPHOCYTIC INFILTRATION AND SURVIVAL IN RECTAL-CANCER
LYMPHOCYTIC INFILTRATION AND SURVIVAL IN RECTAL-CANCER
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DOI：
10.1136/jcp.39.6.585
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发表时间：
1986-06-01
影响因子：
3.4
通讯作者：
JASS, JR
中科院分区：
文献类型：
--
作者：
JASS, JR
对447例直肠癌标本的淋巴细胞浸润进行了半定量评估。明显、中度和少量淋巴细胞浸润的校正五年生存率分别为92%、65%和36%。在观察者内研究中显示分级具有重现性（观察一致率为81%，预期一致率为34%，kappa系数为0.72）。在分级和分期相关变量的多变量生存分析中，淋巴细胞浸润是预后模型中唯一被接受的分级相关变量。该模型还包括淋巴结转移的数量和肿瘤扩散的程度。这表明，上皮和粘膜相关淋巴组织（MALT）之间的正常相互作用交通的保护信号低级别的增长。淋巴细胞浸润和恶性上皮分泌成分表达之间的相关性支持了这一点。
Lymphocytic infiltration was assessed semiquantitatively in 447 specimens of rectal cancer. Corrected five year survivals for pronounced, moderate and little lymphocytic infiltration were 92%, 65% and 36%, respectively. Grading was shown to be reproducible in an intraobserver study (observed agreement 81% expected agreement 34% kappa coefficient 0.72). In the multivariate survival analysis of grade and stage related variables lymphocytic infiltration was the only grade related variable to be accepted within the prognostic model. This model also included the number of lymph node metastases and the extent of tumour spread. It is suggested that the conservation of the normal interactive traffic between epithelium and mucosa associated lymphoid tissue (MALT) signals a low grade growth. This is supported by the association between lymphocytic infiltration and the expression of secretory component by malignant epithelium.