IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights.
IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights.
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上皮间质转化中的 IGF-IR 信号转导和靶向 IGF-IR 治疗：概述和新见解
DOI：
10.1186/s12943-016-0576-5
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发表时间：
2017-01-30
期刊：
影响因子：
37.3
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Li H;Batth IS;Qu X;Xu L;Song N;Wang R;Liu Y
胰岛素样生长因子- i （IGF-I）信号传导可诱导上皮细胞向间质转化（EMT）程序，并有助于几种亚型肿瘤的转移和耐药。在临床前研究中，靶向胰岛素样生长因子- 1受体（IGF-IR）显示出良好的抗肿瘤作用。不幸的是，对抗igf - ir治疗的高期望在许多临床试验中遇到了挑战和失望。本文就IGF-I/IGF-IR信号通路对EMT的调控及靶向IGF-IR治疗的耐药机制进行综述。最重要的是，我们解决了IGF-I/ igf - ir相关EMT进展调节中的几个因素，这些因素可能是靶向治疗中潜在的预测性生物标志物。
The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical studies, targeting of the insulin-like growth factor-I receptor (IGF-IR) showed promising anti-tumor effects. Unfortunately, high expectations for anti-IGF-IR therapy encountered challenge and disappointment in numerous clinical trials. This review summarizes the regulation of EMT by IGF-I/IGF-IR signaling pathway and drug resistance mechanisms of targeting IGF-IR therapy. Most importantly, we address several factors in the regulation of IGF-I/IGF-IR-associated EMT progression that may be potential predictive biomarkers in targeted therapy.