Distemper virus encephalitis exerts detrimental effects on hippocampal neurogenesis
Distemper virus encephalitis exerts detrimental effects on hippocampal neurogenesis
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犬瘟热病毒脑炎对海马神经发生产生有害影响
DOI：
10.1111/j.1365-2990.2011.01218.x
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发表时间：
2012
影响因子：
5
通讯作者：
H Potschka
中科院分区：
文献类型：
--
作者：
von Rüden EL;Avemary J;Zellinger C;Algermissen D;Bock P;Beineke A;Baumgärtner W;Stein VM;Tipold A;H Potschka
E-L von Rüden，J. Avemary，C. Zellinger，D. Algermissen，P. Bock，A. Beineke，W.鲍姆加特纳Stein，A.蒂波尔德和H. Potschka（2012）Neuropathology and Applied Neurobiology 38，426- 442 Distemper virus encephalitis employs deteriorative effects on hippocampal neurogenesis目的：尽管了解脑炎症对海马神经发生的影响，但关于病毒性脑炎对齿状颗粒细胞神经发生的影响的数据迄今为止是有限的。犬瘟热被认为是一种有趣的病毒性脑炎模型，它可能与慢性进展性疾病过程相关，并可能导致症状性癫痫发作。方法：为了确定犬瘟热病毒（CDV）感染对海马神经发生的影响，我们比较了感染和未感染癫痫发作的犬、非病毒病因癫痫犬和无中枢神经系统疾病犬的死后组织。结果：大多数感染和非病毒病因癫痫的动物显示出低于对照组平均年龄的神经元祖细胞数量。与年龄匹配的对照组相比，病毒感染伴或不伴癫痫发作使神经元祖细胞的平均数量显著减少了43%和76%。Ki-67标记表明，海马细胞增殖既不受感染影响，也不受非病毒病因的癫痫影响。对表达caspase-3、doublecortin或Ki-67的细胞中CDV感染的分析表明，神经元祖细胞的感染极为罕见，并表明感染可能损害未分化的祖细胞，阻碍神经元分化并促进神经胶质分化。在犬瘟热感染犬中，凝集素反应性小胶质细胞数量的个体间差异很明显。统计分析没有显示凝集素反应性小胶质细胞和神经元祖细胞的数量之间的相关性。结论：我们的数据表明，病毒性脑炎与癫痫发作和不发作可以对海马神经发生产生不利影响，这可能有助于疾病的长期后果。犬瘟热病毒对Ki-67标记的细胞没有显著影响，表明感染影响了新生细胞的神经元分化和存活，而不是海马细胞增殖。
E.‐L. von Rüden, J. Avemary, C. Zellinger, D. Algermissen, P. Bock, A. Beineke, W. Baumgärtner, V. M. Stein, A. Tipold and H. Potschka (2012)Neuropathology and Applied Neurobiology38,426–442Distemper virus encephalitis exerts detrimental effects on hippocampal neurogenesisAims:Despite knowledge about the impact of brain inflammation on hippocampal neurogenesis, data on the influence of virus encephalitis on dentate granule cell neurogenesis are so far limited. Canine distemper is considered an interesting model of virus encephalitis, which can be associated with a chronic progressing disease course and can cause symptomatic seizures.Methods:To determine the impact of canine distemper virus (CDV) infection on hippocampal neurogenesis, we compared post‐mortem tissue from dogs with infection with and without seizures, from epileptic dogs with non‐viral aetiology and from dogs without central nervous system diseases.Results:The majority of animals with infection and with epilepsy of non‐viral aetiology exhibited neuronal progenitor numbers below the age average in controls. Virus infection with and without seizures significantly decreased the mean number of neuronal progenitor cells by 43% and 76% as compared to age‐matched controls. Ki‐67 labelling demonstrated that hippocampal cell proliferation was neither affected by infection nor by epilepsy of non‐viral aetiology. Analysis of CDV infection in cells expressing caspase‐3, doublecortin or Ki‐67 indicated that infection of neuronal progenitor cells is extremely rare and suggests that infection might damage non‐differentiated progenitor cells, hamper neuronal differentiation and promote glial differentiation. A high inter‐individual variance in the number of lectin‐reactive microglial cells was evident in dogs with distemper infection. Statistical analyses did not reveal a correlation between the number of lectin‐reactive microglia cells and neuronal progenitor cells.Conclusions:Our data demonstrate that virus encephalitis with and without seizures can exert detrimental effects on hippocampal neurogenesis, which might contribute to long‐term consequences of the disease. The lack of a significant impact of distemper virus on Ki‐67‐labelled cells indicates that the infection affected neuronal differentiation and survival of newborn cells rather than hippocampal cell proliferation.
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影响因子：
3.3
作者：
V. Stein;M. Czub;Nicole M S Schreiner;P. Moore;M. Vandevelde;A. Zurbriggen;A. Tipold
通讯作者：
V. Stein;M. Czub;Nicole M S Schreiner;P. Moore;M. Vandevelde;A. Zurbriggen;A. Tipold
犬瘟热的少突胶质细胞病理学
影响因子：
12.7
作者：
A. Zurbriggen;I. Schmid;H. Graber;M. Vandevelde
通讯作者：
M. Vandevelde
犬瘟热病毒和多发性硬化症
DOI：
--
发表时间：
1978
期刊：
The Lancet
影响因子：
--
作者：
S. Krakowka;A. Koestner
通讯作者：
A. Koestner
DOI：
--
发表时间：
1998
期刊：
Clinical techniques in small animal practice
影响因子：
--
作者：
W. Thomas
通讯作者：
W. Thomas
影响因子：
12.7
作者：
Gröters, S;Alldinger, S;Baumgärtner, W
通讯作者：
Baumgärtner, W