Selective binding of Trypanosoma cruzi to host cell membrane polypeptides.
Selective binding of Trypanosoma cruzi to host cell membrane polypeptides.
复制标题
克氏锥虫与宿主细胞膜多肽的选择性结合。
DOI：
10.1128/iai.58.1.1-6.1990
复制
发表时间：
1990
影响因子：
3.1
通讯作者：
Kuhn,RE
中科院分区：
文献类型：
--
作者：
Davis,CD;Kuhn,RE
采用一种改进的免疫印迹技术，在分子水平上研究了克氏锥虫与哺乳动物宿主细胞的结合作用。克氏锥虫与两种分子质量分别约为32千和34千道尔顿的宿主细胞膜多肽之间存在特异性结合作用。这种分子相互作用与克氏毛滴虫的抗原提取物和寄生虫的活体、感染性类鞭毛虫阶段观察到，表明观察到的现象可能与寄生虫入侵前最初附着在宿主细胞膜上有关。
An adaptation of the immunoblotting technique was used to investigate binding interactions between Trypanosoma cruzi and mammalian host cells at the molecular level. A specific binding interaction was observed between T. cruzi and two host cell membrane polypeptides with molecular masses of approximately 32 and 34 kilodaltons. This molecular interaction was observed with antigen extracts of T. cruzi and with live, infective trypomastigote stages of the parasite, suggesting that the observed phenomenon may have relevance to the initial attachment of the parasite to the host cell membrane before invasion.