Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation.
Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation.
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DOI：
10.1186/s13578-016-0089-3
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发表时间：
2016
影响因子：
7.5
通讯作者：
Tan M
中科院分区：
文献类型：
--
作者：
Lim S;Smith KR;Lim ST;Tian R;Lu J;Tan M
线粒体是在大多数真核细胞中发现的双膜结合细胞器。它们产生细胞的大部分能量供应三磷酸腺苷（ATP）。蛋白质磷酸化和去磷酸化是细胞信号网络调节的关键机制，对几乎所有细胞功能都是必不可少的。几十年来，线粒体被认为是自主细胞器，其功能只是为细胞生存和增殖提供能量，并且被认为独立于细胞信号网络。因此，线粒体激酶和磷酸酶的磷酸化和去磷酸化过程在很大程度上被忽视。然而，近年来积累的证据对大肠杆菌定位激酶/磷酸酶改变了这一长期的看法。线粒体越来越被认为是细胞信号传导的枢纽，许多激酶和磷酸酶已被报道定位于线粒体中并发挥重要功能。然而，关于线粒体定位的证据的强度以及所报道的激酶和磷酸酶的活性变化很大，并且关于这些激酶/磷酸酶如何易位到线粒体的详细机制、它们随后的功能以及它们的定位的生理和病理意义仍然知之甚少。在这里，我们提供了一个最新的观点在这一领域的最新进展，重点是线粒体激酶/磷酸酶在癌症和其他几种疾病的影响。
The mitochondria are double membrane-bound organelles found in most eukaryotic cells. They generate most of the cell’s energy supply of adenosine triphosphate (ATP). Protein phosphorylation and dephosphorylation are critical mechanisms in the regulation of cell signaling networks and are essential for almost all the cellular functions. For many decades, mitochondria were considered autonomous organelles merely functioning to generate energy for cells to survive and proliferate, and were thought to be independent of the cellular signaling networks. Consequently, phosphorylation and dephosphorylation processes of mitochondrial kinases and phosphatases were largely neglected. However, evidence accumulated in recent years on mitochondria-localized kinases/phosphatases has changed this longstanding view. Mitochondria are increasingly recognized as a hub for cell signaling, and many kinases and phosphatases have been reported to localize in mitochondria and play important functions. However, the strength of the evidence on mitochondrial localization and the activities of the reported kinases and phosphatases vary greatly, and the detailed mechanisms on how these kinases/phosphatases translocate to mitochondria, their subsequent function, and the physiological and pathological implications of their localization are still poorly understood. Here, we provide an updated perspective on the recent advancement in this area, with an emphasis on the implications of mitochondrial kinases/phosphatases in cancer and several other diseases.