A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors.
A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors.
复制标题
5-HT 转运蛋白连接启动子区 (5-HTTLPR) 多态性及其与饮酒问题和性危险行为的关联的综述。
DOI：
10.1007/s12687-015-0253-1
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发表时间：
2016
影响因子：
1.9
通讯作者：
Dévieux,JessyG
中科院分区：
文献类型：
--
作者：
Rubens,Muni;Ramamoorthy,Venkataraghavan;Attonito,Jennifer;Saxena,Anshul;Appunni,Sandeep;Shehadeh,Nancy;Dévieux,JessyG
Alcohol use and sexual risk behaviors are multidimensional phenomena involving many genetic and environmental factors. 5-HT transporter linked promoter region (5-HTTLPR) polymorphism constitutes an important factor affecting alcohol use problems and risky sexual behaviors. This paper narratively reviews studies on 5-HTTLPR polymorphism and its associations with alcohol use problems and sexual risk behaviors. We searched the electronic databases, PubMed, Ovid, and Google Scholar for articles using MeSH terms. Relevant articles were reviewed and eligible articles were selected for the study. Many studies have reported a significant but moderate association between 5-HTTLPR polymorphism and alcohol use problems. These studies have implicated the presence of at least one S allele to be associated with significant increases in alcohol use problems. Similarly, some studies associate the S allele with increased sexual risk behaviors. Effective alcohol cessation initiatives and STI/HIV prevention programs should be modified to account for 5-HTTLPR polymorphism before planning interventions; genetic effects could moderate the intervention effect.
