Accommodating phylogenetic uncertainty in evolutionary studies
Accommodating phylogenetic uncertainty in evolutionary studies
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DOI：
10.1126/science.288.5475.2349
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发表时间：
2000-06-30
期刊：
影响因子：
56.9
通讯作者：
Masly, JP
中科院分区：
文献类型：
--
作者：
Huelsenbeck, JP;Rannala, B;Masly, JP
许多进化研究使用跨物种的比较来检测自然选择的证据，并检查性状进化的速率，这些研究中的统计分析通常是通过物种同源性来进行的，以适应共同进化历史的影响。遗传学通常被认为是已知的，没有错误;这个假设是有问题的，因为推断的遗传学受到随机和系统误差的影响。我们描述了适应系统发育的不确定性在进化研究中的贝叶斯推理的方法。这些方法是计算密集型的，但一般足以适用于大多数比较进化研究。
Many evolutionary studies use comparisons across species to detect evidence of natural selection and to examine the rate of character evolution, Statistical analyses in these studies are usually performed by means of a species phylogeny to accommodate the effects of shared evolutionary history. The phylogeny is usually treated as known without error; this assumption is problematic because inferred phylogenies are subject to both stochastic and systematic errors. We describe methods for accommodating phylogenetic uncertainty in evolutionary studies by means of Bayesian inference. The methods are computationally intensive but general enough to be applied in most comparative evolutionary studies.