Lipid digestion and absorption.
Lipid digestion and absorption.
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DOI：
10.1542/peds.75.1.151
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发表时间：
1985-01
期刊：
影响因子：
8
通讯作者：
J. Watkins
中科院分区：
文献类型：
--
作者：
J. Watkins
营养脂类对早产儿和足月儿发育的重要性使人们把研究重点放在脂肪消化和吸收的机制上。综述了人乳脂肪球独特的理化性质。重点放在已经出现的关于甘油三酯水解和溶解的脂解产物的管腔内阶段的新的理解。探讨了胰脂肪酶、辅脂酶和磷脂酶A2系统的作用机制，以及胃内脂解对启动脂质消化的重要性。最后，胆汁酸胶束的形成及其对营养脂质的溶解和吸收的作用方面进行检查，鉴于出生后的适应，发生断奶和引进替代营养源的年龄较大的婴儿。
The importance of nutrient lipids to the developing preterm and term infant has served to focus investigations upon the mechanisms of fat digestion and absorption. The unique physical-chemical properties of the human milk fat globule have been reviewed. Emphasis is placed on the newer understandings that have emerged concerning the intraluminal phase of triglycerides hydrolysis and solubilization of the lipolytic products. The mechanisms of action of the pancreatic lipase, colipase, and phospholipase A2 system, and the importance of intragastric lipolysis for initiating the lipid digestion are explored. Lastly, aspects of bile acid micelle formation and its role on nutrient lipid solubilization and absorption are examined in view of the postnatal adaptations that occur with weaning and the introduction of alternative nutrient sources to the older infant.