Cell cycling and patterned cell proliferation in the wing primordium of Drosophila
Cell cycling and patterned cell proliferation in the wing primordium of Drosophila
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DOI：
10.1073/pnas.93.2.640
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发表时间：
1996-01-23
影响因子：
11.1
通讯作者：
GarciaBellido, A
中科院分区：
文献类型：
--
作者：
Milan, M;Campuzano, S;GarciaBellido, A
果蝇想象翼原基细胞增殖模式具有空间和时间上的异质性。直接观察细胞周期的S期、G期(2)和有丝分裂期的细胞，可以发现在整个发育过程中有几个不变的特征。在不同细胞周期阶段，盘状细胞的比例是恒定的，大多数留在G期(1)。细胞周期不同阶段的细胞主要以小的同步性集群出现，这些集群非克隆衍生，但源于局部细胞间相互作用的变化。集群同步发生在S阶段之前和G(2)/M阶段。细胞分裂的速率既不是恒定的，也不是克隆的特征。细胞周期进程是线性的，而不是同心的。集群出现在整个椎间盘，但与假定的翅膀模式，隔室边界和静脉克隆限制有关的对称性。
The pattern of cell proliferation in the Drosophila imaginal wing primordium is spatially and temporally heterogeneous. Direct visualization of cells in S, G(2), and mitosis phases of the cell cycle reveals several features invariant throughout development, The fraction of cells in the disc in the different cell cycle stages is constant, the majority remaining in G(1). Cells in the different phases of the cell cycle mainly appear in small synchronic clusters that are non-clonally derived but result from changing local cell-cell interactions. Cluster synchronization occurs before S and in the G(2)/M phases. Rates of cell division are neither constant nor clonal features. Cell cycle progression is linear rather than concentric. Clusters appear throughout the disc but with symmetries related to presumptive wing patterns, compartment boundaries, and vein clonal restrictions.