Subjective depth of field in presence of 4th-order and 6th-order Zernike spherical aberration using adaptive optics technology

Subjective depth of field in presence of 4th-order and 6th-order Zernike spherical aberration using adaptive optics technology
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DOI:
10.1016/j.jcrs.2010.07.022
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发表时间:
2010-12-01
影响因子:
2.8
通讯作者:
Legras, Richard
Legras, Richard
中科院分区:
医学2区
文献类型:
--
作者:
Benard, Yohann;Lopez-Gil, Norberto;Legras, Richard

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目的:研究四级球差及其与六级球差的组合对主观景深的影响,并分析图像质量指标在预测影响方面的准确性。设置:澳大利亚科顿实验室,法国巴黎南大学,奥赛,法国设计:病例系列。方法:主观景深定义为目标(3个高对比度字母,20/50)被感知的散焦范围。采用0.18级屈光度(D)阶跃测量视野深度,增加球差:+/-0.3微米和+/-0.6微米四级球差,瞳孔3.0 mm和6.0 mm,+/-0.3微米,六级球差+/-0.1微米六级球差。结果:增加0.3和+/-0.6微米四级球差,视深分别增加30%和45%。四级球差和六级球差的组合比单独使用四级球差增加了景深(即63%),而相同符号的四级球差和六级球差的组合没有增加景深(即24%)。而景深的中点可以通过图像质量指标来预测,但没有找到一个很好的预测不良景深的指标。结论:主观景深随着符号相反的四级球差和六级球差的增加而增加,但不能用图像质量指标预测。
PURPOSE: To study the impact on the subjective depth of field of 4th-order spherical aberration and its combination with 6th-order spherical aberration and analyze the accuracy of image-quality metrics in predicting the impact.SETTING: Laboratoire Aime Cotton, Centre National de la Recherche Scientifique, Universite Paris-Sud, Orsay, France.DESIGN: Case series.METHODS: Subjective depth of field was defined as the range of defocus at which the target (3 high-contrast letters at 20/50) was perceived acceptable. Depth of field was measured using 0.18 diopter (D) steps in young subjects with the addition of the following spherical aberration values: +/- 0.3 mu m and +/- 0.6 mu m 4th-order spherical aberration with 3.0 mm and 6.0 mm pupils and +/- 0.3 mu m 4th-order spherical aberration with +/- 0.1 mu m 6th-order spherical aberration for 6.0 mm pupils.RESULTS: The addition of 0.3 and +/- 0.6 mu m 4th-order spherical aberration increased depth of field by 30% and 45%, respectively. The combination of 4th-order spherical aberration and 6th-order spherical aberration of opposite signs increased depth of field more than 4th-order spherical aberration alone (ie, 63%), while the combination of 4th-order spherical aberration and 6th-order spherical aberration of the same signs did not (ie, 24%). Whereas the midpoint of the depth of field could be predicted by image-quality metrics, none was found a good predictor of objectionable depth of field.CONCLUSION: Subjective depth of field increased when 4th-order spherical aberration and 6th-order spherical aberration of opposite signs were added but could not be predicted with image-quality metrics.