Reduction of C-reactive protein levels through use of a multivitamin
Reduction of C-reactive protein levels through use of a multivitamin
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DOI：
10.1016/j.amjmed.2003.08.024
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发表时间：
2003-12-15
影响因子：
5.9
通讯作者：
Kampert, JB
中科院分区：
文献类型：
--
作者：
Church, TS;Earnest, CP;Kampert, JB
目的：C反应蛋白水平升高与心血管疾病和糖尿病的风险相关。我们研究了多种维生素是否能降低C反应蛋白水平。方法：我们对一项为期6个月的随机、双盲、安慰剂对照试验进行了事后亚组分析。患者（n = 87;平均年龄53岁），其冷冻血浆样品可用;在基线时没有炎症状况;并且在研究期间没有住院、服用抗生素、吸烟或开始他汀类药物治疗。结果：在6个月时，复合维生素组的C-反应蛋白水平显著低于安慰剂组（组间差异= -0.91 mg/L; 95%可信区间：-1.52 to -0.30; P = 0.005）。C反应蛋白水平的降低在基线水平升高（大于或等于1.0 mg/L）的患者中最为明显。在测量的六种维生素中（C、E、B-6、B-12、叶酸和β胡萝卜素），仅维生素B-6（基线：r =-0.31，P = 0.003; 6个月：r =-0.29，P = 0.006）和维生素C（基线：r =-0.25，P = 0.02）与C反应蛋白水平呈负相关。在一项随机、双盲、安慰剂对照研究的事后分析中，复合维生素的使用与较低的C反应蛋白水平相关。其他类似配方的多效唑可能会产生相当的结果。(C)2003年，Excerpta Medica Inc.
PURPOSE: Elevated C-reactive protein levels are associated with the risk of cardiovascular disease and diabetes. We examined whether multivitamins reduce C-reactive protein levels.METHODS: We performed a post hoc subgroup analysis of a 6-month, randomized, double-blind, placebo-controlled trial. Patients (n = 87; mean age, 53 years) for whom frozen plasma samples were available; who did not have an inflammatory condition at baseline; and who were not hospitalized, taking antibiotics, smoking, or starting statin therapy during the study were included. C-reactive protein and plasma vitamin levels were measured at baseline and 6 months.RESULTS: At 6 months, C-reactive protein levels were significantly lower in the multivitamin group than in the placebo group (between-group difference = -0.91 mg/L; 95% confidence interval: -1.52 to -0.30; P = 0.005). The reduction in C-reactive protein levels was most evident in patients who had elevated levels (greater than or equal to1.0 mg/L) at baseline. Of the six vitamins measured (C, E, B-6, B-12, folate, and beta carotene), only vitamin B-6 (baseline: r = -0.31, P = 0.003; 6 months: r = -0.29, P = 0.006) and vitamin C (baseline: r = -0.25, P = 0.02) were inversely associated with C-reactive protein level.CONCLUSION: In a post hoc analysis of a randomized, double-blind, placebo-controlled study, multivitamin use was associated with lower C-reactive protein levels. Other similarly formulated multivitamins may yield comparable results. (C) 2003 by Excerpta Medica Inc.