Report from the American Society of Transplantation on frailty in solid organ transplantation
Report from the American Society of Transplantation on frailty in solid organ transplantation
复制标题
DOI：
10.1111/ajt.15198
复制
发表时间：
2019-04-01
影响因子：
8.8
通讯作者：
Lai, Jennifer C.
中科院分区：
文献类型：
--
作者：
Kobashigawa, Jon;Dadhania, Darshana;Lai, Jennifer C.
由美国移植学会（AST）赞助并由美国肾脏病学会（ARF），美国移植外科医生学会（ASTS）和加拿大移植学会（CST）认可的肾，肝，心脏和肺移植脆弱性共识会议于2018年2月11日在亚利桑那州凤凰城举行。通过预定的电话会议，移植界的投入使人们能够广泛讨论当前虚弱的概念，探索移植候选人虚弱风险评估和移植后管理的最佳实践，并为未来的研究提出想法。目前对脆弱性的理解是由每个实体器官组汇编的，并在本文中介绍。虚弱是等待器官移植的终末期器官疾病患者的常见症状，并影响等待名单和移植后期间的死亡率。测量每个器官组虚弱程度的最佳方法尚未确定，但研究正在进行中。逆转虚弱的干预措施在器官组之间各不相同，似乎很有希望。这次会议实现了其目的，强调器官移植中脆弱性的重要性，并为该领域的进一步讨论和研究播下种子。
A consensus conference on frailty in kidney, liver, heart, and lung transplantation sponsored by the American Society of Transplantation (AST) and endorsed by the American Society of Nephrology (ASN), the American Society of Transplant Surgeons (ASTS), and the Canadian Society of Transplantation (CST) took place on February 11, 2018 in Phoenix, Arizona. Input from the transplant community through scheduled conference calls enabled wide discussion of current concepts in frailty, exploration of best practices for frailty risk assessment of transplant candidates and for management after transplant, and development of ideas for future research. A current understanding of frailty was compiled by each of the solid organ groups and is presented in this paper. Frailty is a common entity in patients with end-stage organ disease who are awaiting organ transplantation, and affects mortality on the waitlist and in the posttransplant period. The optimal methods by which frailty should be measured in each organ group are yet to be determined, but studies are underway. Interventions to reverse frailty vary among organ groups and appear promising. This conference achieved its intent to highlight the importance of frailty in organ transplantation and to plant the seeds for further discussion and research in this field.