CD8+ T cell subsets and chronic obstructive pulmonary disease
CD8+ T cell subsets and chronic obstructive pulmonary disease
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DOI：
10.1164/ajrccm.160.supplement_1.10
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发表时间：
1999-11-01
影响因子：
24.7
通讯作者：
O'Connor, BJ
中科院分区：
文献类型：
--
作者：
Kemeny, DM;Vyas, B;O'Connor, BJ
COPD是一种使人衰弱和进行性的病症，其中气道变得不可逆地阻塞并且肺部逐渐受损。与哮喘不同，我们对启动和驱动这一过程的细胞知之甚少。研究表明，CD 8（+）T细胞在COPD患者的肺部过度表达，并且与肺功能呈负相关。然而，并非所有的CD 8（+）T细胞都是相似的，并且已经描述了产生IFN-γ但不产生IL-4（Tc 1）、IL-4但不产生IFN-γ（Tc 2）以及产生两者（Tc 0）的亚群。本文重点介绍了CD 8（+）T细胞亚群的特点，并考虑了它们在慢性阻塞性肺疾病（COPD）中的潜在作用。
COPD is a debilitating and progressive condition in which the airways become irreversibly obstructed and the lungs progressively damaged. Unlike asthma, we know little about the cells that initiate and drive this process. Research has shown that CD8(+) T cells are overrepresented in the lungs of patients with COPD and that they are inversely related to lung function. However, not all CD8(+) T cells are alike and subsets that make IFN-gamma but not IL-4 (Tc1), IL-4 but not IFN-gamma (Tc2) as well as those that make both (Tc0) have been described. This article focuses on the characteristics of CD8(+) T cell subsets and considers their potential contribution to chronic obstructive pulmonary disease (COPD).