Intra-airway gas transport during high-frequency chest vibration with tracheal insufflation in dogs.
Intra-airway gas transport during high-frequency chest vibration with tracheal insufflation in dogs.
复制标题
犬气管充气时高频胸部振动期间气道内气体输送。
DOI：
10.1152/jappl.1995.79.1.243
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Grotberg,JB
中科院分区：
文献类型：
--
作者：
Gavriely,N;Eckmann,DM;Grotberg,JB
高频胸外振动与气管吹气（高频振动通气）先前已被证明是一种有效的模式，人工通气的实验动物。为了研究高频振动通气（频率30 Hz，振幅0.4 cm）期间气道内气体混合，我们使用了单次呼吸洗脱曲线的分析，该曲线给出了相对于无振动情况的振动诱导混合系数分布。在六种速率（0.05-0.4 l.min-1.kg-1）、三种吹入持续时间（2、4和7 s）、吹入导管出口在三个位置（隆突、气管和支气管）、振动打开和关闭的情况下，在恒流吹入期间收集四只麻醉犬的数据。振动增强气道内气体混合14.1 +/- 3.9倍，增强分布的峰值位于距气道开口125 +/- 29 ml处，分布宽度为121 +/- 29 ml。随着吹气流量的增加，增强峰值的位置向肺泡区移动，峰值幅度减小。改变吹气持续时间和导管位置不影响振动引起的气道内混合。外部胸部振动引起气道内气体混合的显著增加，将肺泡气体带到中心气道。当新鲜气体吹入气管隆突区域时，这导致肺气体输送总体增加。
High-frequency external chest vibration with tracheal insufflation (high-frequency vibration ventilation) has previously been shown to be an effective mode of artificial ventilation in experimental animals. To investigate the intra-airway gas mixing during high-frequency vibration ventilation (frequency 30 Hz, amplitude 0.4 cm), we used an analysis of the single-breath washout curve that gives the vibration-induced mixing coefficient distribution relative to the no-vibration situation. Data from four anesthetized dogs were collected during constant-flow insufflation at six rates (0.05–0.4 l.min-1.kg-1), at three insufflation durations (2, 4, and 7 s), and with the insufflation catheter outlet at three positions (carina, trachea, and a bronchus) while the vibration was on and off. Vibration enhanced intra-airway gas mixing 14.1 +/- 3.9-fold, with the peak of the enhancement distribution located 125 +/- 29 ml from the airway opening and a distribution width of 121 +/- 29 ml. As insufflation flow increased, the position of the peak enhancement shifted toward the alveolar zone and diminished in peak amplitude. Changing the insufflation duration and the catheter position did not affect the intra-airway mixing induced by vibration. External chest vibration causes a substantial increase of intra-airway gas mixing, bringing alveolar gas to central airways. This leads to overall increased pulmonary gas transport when fresh gas is insufflating the tracheal carina area.