Daily total physical activity level and total cancer risk in men and women: Results from a large-scale population-based cohort study in Japan
Daily total physical activity level and total cancer risk in men and women: Results from a large-scale population-based cohort study in Japan
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DOI：
10.1093/aje/kwn146
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发表时间：
2008-08-15
影响因子：
5
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Inoue, Manami;Yamamoto, Seiichiro;Tsugane, Shoichiro
总体力活动水平对癌症风险的影响尚未完全阐明，特别是在非西方，相对较瘦的人群中。作者在日本公共卫生中心的前瞻性研究中前瞻性地检查了每日总体力活动（使用代谢当量/日评分）与随后癌症风险之间的关联。在1995年至1999年期间，对79,771名年龄在45-74岁之间的日本普通人群男性和女性进行了问卷调查，随访了2004年的总癌症发病率（4,334例）。与最低四分位数的受试者相比，增加每日体力活动与男女癌症风险显著降低相关。在男性中，第二、第三和最高四分位数的风险比为1.00（95%置信区间（CI）：0.90，1.11），0.96（95% CI：0.86，1.07）和0.87（95% CI：0.78，0.96）（趋势p = 0.005）;女性的风险比为0.93（95% CI：0.82，1.05）、0.84（95% CI：0.73，0.96）和0.84（95% CI：0.73，0.97）（趋势p = 0.007）。女性比男性更明显地观察到风险降低，特别是在老年人和那些经常从事休闲运动或体育锻炼的人中。按地点划分，观察到男性结肠癌、肝癌和胰腺癌以及女性胃癌的风险降低。增加日常体力活动可能有助于预防相对较瘦人群的癌症。
The impact of total physical activity level on cancer risk has not been fully clarified, particularly in non-Western, relatively lean populations. The authors prospectively examined the association between daily total physical activity (using a metabolic equivalents/day score) and subsequent cancer risk in the Japan Public Health Center-based Prospective Study. A total of 79,771 general-population Japanese men and women aged 45-74 years who responded to a questionnaire in 1995-1999 were followed for total cancer incidence (4,334 cases) through 2004. Compared with subjects in the lowest quartile, increased daily physical activity was associated with a significantly decreased risk of cancer in both sexes. In men, hazard ratios for the second, third, and highest quartiles were 1.00 (95% confidence interval (CI): 0.90, 1.11), 0.96 (95% CI: 0.86, 1.07), and 0.87 (95% CI: 0.78, 0.96), respectively (p for trend = 0.005); in women, hazard ratios were 0.93 (95% CI: 0.82, 1.05), 0.84 (95% CI: 0.73, 0.96), and 0.84 (95% CI: 0.73, 0.97), respectively (p for trend = 0.007). The decreased risk was more clearly observed in women than in men, especially among the elderly and those who regularly engaged in leisure-time sports or physical exercise. By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population.