A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
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DOI：
10.1093/emboj/17.16.4753
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发表时间：
1998-08-17
期刊：
影响因子：
11.4
通讯作者：
Okamura, H
中科院分区：
文献类型：
--
作者：
Takumi, T;Taguchi, K;Okamura, H
MPer3是哺乳动物周期基因家族中的一个新成员，与mPer1、mPer2和果蝇周期基因一样，在小鼠脑中的表达模式也具有二聚化PAS结构域和细胞质定位结构域。MPer3转录本在视交叉上核(SCN)表现出明显的昼夜节律。在生物钟的任何阶段，mPer3的表达都不受光照的诱导，这使得该基因有别于mPer1和mPer2。在终板血管层(OVLT)的SCN外也发现了mPer3的循环表达，OVLT是调节节律性促性腺激素产生和热原引起的发热现象的一个潜在的关键区域。因此，mPer3可能对SCN内外的起搏功能都有贡献。
A new member of the mammalian period gene family, mPer3, was isolated and its expression pattern characterized in the mouse brain, Like mPer1, mPer2 and Drosophila period, mPer3 has a dimerization PAS domain and a cytoplasmic localization domain. mPer3 transcripts showed a clear circadian rhythm in the suprachiasmatic nucleus (SCN). Expression of mPer3 was not induced by exposure to light at any phase of the clock, distinguishing this gene from mPer1 and mPer2. Cycling expression of mPer3 was also found outside the SCN in the organum vasculosum lamina terminalis (OVLT), a potentially key region regulating rhythmic gonadotropin production and pyrogen-induced febrile phenomena. Thus, mPer3 may contribute to pacemaker functions both inside and outside the SCN.