Biological and Clinicopathological Implications of Beta-3-N-acetylglucosaminyltransferase 8 in Triple-negative Breast Cancer
Biological and Clinicopathological Implications of Beta-3-N-acetylglucosaminyltransferase 8 in Triple-negative Breast Cancer
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DOI：
10.21873/anticanres.14837
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发表时间：
2021-02-01
影响因子：
2
通讯作者：
Irimura, Tatsuro
中科院分区：
文献类型：
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作者：
Okazaki, Misato;Mogushi, Kaoru;Irimura, Tatsuro
背景/目的：三阴性乳腺癌（TNBC）仍然难以治疗，需要新的分子靶点。在这里，我们研究了糖基转移酶基因对 TNBC 患者生存的影响。患者和方法：使用癌症基因组图谱数据比较 TNBC 患者中 101 个糖基转移酶基因的 mRNA 表达水平与患者生存的相关性。应用 β-3-N-乙酰葡萄糖氨基转移酶 8 (B3GNT8) 抗体来研究 23 个 TNBC 手术标本中的 B3GNT8 蛋白分布和表达水平。结果：B3GNT8 mRNA 水平与无复发生存率呈负相关 (p
Background/Aim: Triple-negative breast cancer (TNBC) remains difficult to treat and new molecular targets are needed. Here, we investigated the impact of glycosyltransferase genes on TNBC patient survival. Patients and Methods: mRNA expression levels of 101 glycosyltransferase genes in TNBC patients were compared for correlation with patient survival using The Cancer Genome Atlas data. An antibody to beta-3-N-acetylgluco-saminyltransferase 8 (B3GNT8) was applied to investigate B3GNT8 protein distribution and expression levels in 23 TNBC surgical specimens. Results: B3GNT8 mRNA levels inversely correlated with relapse-free survival (p