Acquired macrolide resistance in the human intestinal strain Lactobacillus rhamnosus E41 associated with a transition mutation in 23S rRNA genes
Acquired macrolide resistance in the human intestinal strain Lactobacillus rhamnosus E41 associated with a transition mutation in 23S rRNA genes
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DOI：
10.1016/j.ijantimicag.2007.06.002
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发表时间：
2007-10-01
影响因子：
10.8
通讯作者：
Mayo, Baltasar
中科院分区：
文献类型：
--
作者：
Florez, Ana-Belen;Ladero, Victor;Mayo, Baltasar
限制性片段长度多态性和聚合酶链反应（PCR）产物的DNA测序结果表明，一株对大环内酯类抗生素耐药的人源鼠李糖乳杆菌（Lactobacillusrhamnosus）在其23SrRNA基因的2058位（大肠杆菌编号）存在杂合性A → G转换突变。(C)2007年Elsevier B.V.和国际化疗学会。All rights reserved.
Restriction fragment length polymorphism and DNA sequencing of polymerase chain reaction (PCR) products showed that a Lactobacillus rhamnosus strain of human origin resistant to macrolides, from which no resistance determinants have been detected by specific PCR and microarray screening, contained a heterozygous A -> G transition mutation at position 2058 (Escherichia coli numbering) of its 23S rRNA genes. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.