Increase in CIP2A expression is associated with doxorubicin resistance
Increase in CIP2A expression is associated with doxorubicin resistance
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DOI：
10.1016/j.febslet.2011.01.018
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发表时间：
2011-03-09
期刊：
影响因子：
3.5
通讯作者：
Yang, Young
中科院分区：
文献类型：
--
作者：
Choi, Yeon A.;Park, Jeong Su;Yang, Young
蛋白磷酸酶2A（CIP 2A）的癌性抑制剂增加各种癌细胞的迁移和转移。CIP 2A的过表达已显示增加MDA-MB-231细胞的增殖。因此，我们评估了CIP 2A表达是否与对阿霉素的敏感性相关。MDA-MB-231细胞在用阿霉素处理后显示出CIP 2A表达的增加，而MCF-7细胞显示出CIP 2A表达的减少。CIP 2A在MCF-7细胞中的过表达克服了响应于多柔比星处理的细胞增殖抑制。CIP 2A表达不受野生型或突变型p53的影响。然而，突变型p53阻断了HCT 116细胞中阿霉素介导的CIP 2A下调。作为阿霉素介导的CIP 2A表达的调节机制，我们发现磷酸化Akt参与了CIP 2A表达的抑制。(C)2011年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
The cancerous inhibitor of protein phosphatase 2A (CIP2A) increases the migration and metastasis of various cancer cells. Overexpression of CIP2A has been shown to increase the proliferation of MDA-MB-231 cells. We thus assessed whether CIP2A expression is associated with sensitivity to doxorubicin. MDA-MB-231 cells showed an increase in CIP2A expression after treatment with doxorubicin, while MCF-7 cells showed a decrease in CIP2A expression. The overexpression of CIP2A in MCF-7 cells overcame the inhibition of cell proliferation in response to doxorubicin treatment. CIP2A expression was not affected by wild-type or mutant p53. However, mutant p53 blocked doxorubicin-mediated CIP2A down-regulation in HCT116 cells. As a regulation mechanism of doxorubicin-mediated CIP2A expression, we showed that phosphorylated Akt was involved in the suppression of CIP2A expression. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.