Relationship between oxidative stress and essential hypertension
Relationship between oxidative stress and essential hypertension
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DOI：
10.1291/hypres.30.1159
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发表时间：
2007-12-01
影响因子：
5.4
通讯作者：
Bachler, Jean P.
中科院分区：
文献类型：
--
作者：
Rodrigo, Ramon;Prat, Hernan;Bachler, Jean P.
本研究探讨了正常和高血压受试者血压与血液氧化应激相关参数的关系。采用横断面设计对31例高血压患者和35例健康血压正常者进行研究。所有的研究对象都是年龄在35到60岁之间的男性。排除标准为肥胖、血脂异常、糖尿病、吸烟和正在使用任何药物。所有患者均接受24小时动态血压监测和血液和尿液采样。测定红细胞抗氧化酶活性、还原性/氧化性谷胱甘肽比值（GSH/GSSG）和脂质过氧化（丙二醛）。受试者血浆中测定的参数为血浆抗氧化状态、脂质过氧化（8-异前列腺素）、血浆维生素C和E、血压调节剂肾素、醛固酮、内皮素-1和同型半胱氨酸。高血压患者的日间收缩压和舒张压与血浆抗氧化能力呈负相关(r=-0.46, p
This study investigated the association of blood pressure with blood oxidative stress-related parameters in normotensive and hypertensive subjects. A cross-sectional design was applied to 31 hypertensive patients and 35 healthy normotensive subjects. All subjects were men between the ages of 35 and 60 years. Exclusion criteria were obesity, dyslipidemia, diabetes mellitus, smoking and current use of any medication. All patients underwent 24-h ambulatory blood pressure monitoring and sampling of blood and urine. Antioxidant enzymes activity, reduced/oxidized glutathione ratio (GSH/GSSG), and lipid peroxidation (malondialdehyde) were determined in erythrocytes. Parameters measured in the plasma of test subjects were plasma antioxidant status, lipid peroxidation (8-isoprostane), plasma vitamin C and E, and the blood pressure modulators renin, aldosterone, endothelin-1 and homocysteine. Daytime systolic and diastolic blood pressures of hypertensives were negatively correlated with plasma antioxidant capacity (r=-0.46, p