WNTS and WNT receptors as therapeutic tools and targets in human disease processes
WNTS and WNT receptors as therapeutic tools and targets in human disease processes
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DOI：
10.2741/2074
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Moon, Randall T.
中科院分区：
文献类型：
--
作者：
Chien, Andy J.;Moon, Randall T.
将Wnt和Wnt相关蛋白与人类疾病过程联系起来的科学文献的主体继续与基础科学实验室的新发现并行增长，这些新发现进一步表征了Wnt与其受体结合后的精细细胞事件。虽然Wnt介导的信号传导长期以来一直被认为在人类癌症发生中起着重要作用，但越来越多的证据表明Wnt也是炎症和损伤恢复的重要介质。分泌的Wnt配体与其受体的结合为这些信号传导途径的治疗调节提供了有吸引力的和可接近的靶标。一些有希望的初步研究已经解决了在疾病过程中操纵Wnt信号的潜在途径。这篇综述将集中在疾病的过程中涉及的Wnt信号的Wnt结合到其靶受体的水平上的调节。Wnt蛋白、Wnt受体和分泌的Wnt抑制剂由于其细胞外位置而作为潜在的治疗剂和靶标是有吸引力的。此外，由于Wnt信号传导导致多种下游细胞内事件，其中许多尚未完全理解，因此在途径激活的最上游位点靶向该途径也为治疗提供了战略优势。随着Wnt相关疾病的不断增加，我们对Wnt信号传导的生化和分子机制的理解的进步可能最终转化为治疗患者Wnt相关疾病过程的创新方法。
The body of scientific literature linking Wnts and Wnt-associated proteins to human disease processes continues to grow in parallel with new discoveries from basic science laboratories that further characterize the elaborate cellular events following the binding of Wnts to their receptors. While Wnt-mediated signaling has long been known to play a major role in human carcinogenesis, accumulating evidence indicates that Wnts are also important mediators of inflammation and recovery from injury. The binding of secreted Wnt ligands to their receptors offers an attractive and accessible target for therapeutic regulation of these signaling pathways. Several promising preliminary studies have already addressed potential avenues for the manipulation of Wnt signaling in disease processes. This review will focus on disease processes involving the regulation of Wnt signaling at the level of Wnt binding to its target receptors. Wnt proteins, Wnt receptors, and secreted Wnt inhibitors are attractive as potential therapeutic agents and targets due to their extracellular location. In addition, since Wnt signaling results in a diverse array of downstream intracellular events, many of which are not fully understood, the targeting of this pathway at the most upstream site of pathway activation also provides a strategic advantage for therapy. As the list of Wnt-related diseases continues to grow, advances in our understanding of the biochemical and molecular mechanisms underlying Wnt signaling may ultimately translate into innovative ways to treat Wnt-related disease processes in patients.