A DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase.
A DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase.
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DOI：
10.1039/b913943e
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发表时间：
2009-11
影响因子：
4.9
通讯作者：
Xiahong Xu;Z. Nie;Jinhua Chen;Yingchun Fu;Wang Li;Qinpeng Shen;S. Yao
中科院分区：
文献类型：
--
作者：
Xiahong Xu;Z. Nie;Jinhua Chen;Yingchun Fu;Wang Li;Qinpeng Shen;S. Yao
A novel label-free electrochemical strategy for monitoring the activity and inhibition of protein kinase is developed, based on the linkage between the phosphorylated peptide and DNA functionalized Au nanoparticles (DNA-AuNPs) by Zr(4+) and the chronocoulometric response of [Ru(NH(3))(6)](3+) absorbed on the DNA-AuNPs.
