A comparison of rCBF patterns during letter and semantic fluency
A comparison of rCBF patterns during letter and semantic fluency
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DOI：
10.1037//0894-4105.14.3.353
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发表时间：
2000-07-01
期刊：
影响因子：
2.4
通讯作者：
Berman, KF
中科院分区：
文献类型：
--
作者：
Gourovitch, ML;Kirkby, BS;Berman, KF
为了评估字母流畅性和类别流畅性背后的功能性神经解剖结构，对18名正常对照者使用氧 - 15水区域脑血流正电子发射断层扫描进行了研究。三种平衡条件每种都包含6次试验（每次45秒）：字母流畅性（当给予特定字母提示时生成单词）、语义流畅性（当给予特定类别提示时生成单词）以及一个对照条件（生成一周中的天数和一年中的月份）。相对于对照条件，参与者在两种流畅性任务中激活了相似的脑区，包括前扣带回、左侧前额叶区域、丘脑和小脑；在顶叶和颞叶区域发现激活减弱。在对两种流畅性任务的直接比较中，额下回皮质和颞顶叶皮质（被假设参与获取单词发音的语音回路）在字母流畅性任务中比在语义流畅性任务中激活更强，而左侧颞叶皮质（与语义存储的获取相关）在语义流畅性任务中比在字母流畅性任务中激活更强。这项研究确定了字母流畅性和语义流畅性背后神经网络的细微差异，这些差异可能是患者中这些能力分离的基础。
To evaluate the functional neuroanatomies underlying letter and category fluency, 18 normal controls were studied with oxygen-15 water regional cerebral blood how positron emission tomography. Three counterbalanced conditions each consisted of 6 trials (45 s each): letter fluency (generating words when cued with a particular letter), semantic fluency (generating words when cued with a particular category), and a control condition (generating days of the week and months of the year). Relative to the control, participants activated similar brain regions during both fluency tasks, including the anterior cingulate, left prefrontal regions, thalamus, and cerebellum; reductions were found in parietal and temporal regions. In a direct comparison of the 2 fluency tasks, inferior frontal cortex and temporoparietal cortex (hypothesized to participate in a phonologic loop for accessing word pronunciation) were activated more during letter than semantic fluency, whereas left temporal cortex (associated with access to semantic storage) was activated more during semantic than letter fluency. This study identifies subtle differences in the neural networks underlying letter and semantic fluency that may underlie the dissociation of these abilities in patients.