The Immunoglobulin a System
The Immunoglobulin a System
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免疫球蛋白系统
DOI：
10.1007/978-1-4613-4550-3
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
A. Lawton
中科院分区：
文献类型：
--
作者：
J. Mestecky;A. Lawton
第一部分：发育和细胞方面主席：Lars A. Hanson。-与局部和全身免疫有关的IgA系统。-产生iga细胞的起源、分布和分化。-促进sIgA生物合成的细胞类型。讨论1 .肠道相关淋巴细胞和肠道IgA浆细胞。-支气管淋巴组织。人体内IgA的单体和聚合形式的起源。- IgA对人中性粒细胞的嗜细胞性。-讨论二。结构，生物合成和遗传学主席：J. Claude Bennett体外形成的SC-Ig复合物的特性。- S-IgA亚基的关联。-免疫球蛋白亚基组装的调节。-讨论一- e·c·富兰克林，最初的讨论者。-免疫球蛋白聚合物组装机制。-免疫球蛋白a的组装和分泌- IgA2亚类的特殊特征从IgM中获得的J链的物理化学特性-讨论二。主席：Jiri Mestecky。-人IgA骨髓瘤球蛋白的分离、性质和结构。-人IgA骨髓瘤蛋白的氨基酸序列研究。人IgA1骨髓瘤蛋白羧基末端缺失的结构研究。- IgA2m(2)骨髓瘤蛋白的铰链肽。从IgA2免疫球蛋白中分离的糖肽的碳水化合物组成。小鼠α链缺失的IgA骨髓瘤蛋白：与人类α链缺失的比较。讨论1 .分泌性和血清IgA共同合成来源的证据。-人体分泌成分初级结构的研究。用iga特异性细菌蛋白酶从人免疫球蛋白A中产生Fc片段。-人类和动物j链之间的沉淀交叉反应。-人免疫球蛋白A1和A2的二硫桥。-讨论二。- D会议职能主席：弗雷德里克·克劳斯。-分泌性免疫系统在病毒感染中的意义。-分泌性免疫系统在预防呼吸道感染中的作用。免疫在控制小肠抗原摄取中的作用。-人分泌IgA抗A血型抗体通过经典或替代途径缺乏C3激活。讨论1 .细菌粘附于粘膜表面及其分泌抗体的抑制作用。-变形链球菌抗体的特异性在抑制粘附中的意义。猪乳汁中抗传染性胃肠炎病毒的分泌抗体。分泌IgA和通过血清成分直接杀死志贺氏菌。-讨论二。主席：Max D. Cooper。- α链病的最新知识。-人类IgA缺乏的细胞基础。-免疫球蛋白合成细胞膜上的α链决定因子。蛋白质-热量营养不良儿童的分泌和血清IgA-人类尿液中大肠杆菌分泌抗体与血清抗体含量的比较研究。-秘书IgA：青春期的到来。从骨髓瘤和正常人血清中分离的IgA分子的大小异质性类型。21例正常人血清和骨髓浆细胞中IgA亚类的分布选择性IgA缺乏与慢性阻塞性肺疾病的家庭研究-讨论二。会议F: IgA抗体应答对口腔健康的影响主席：Alexander R. Lawton-分泌型IgA抗体的诱导和表征。人鼻外分泌IgA抗体的形成及其活性几种不同免疫方法对兔颌下腺IgA抗体形成细胞反应的影响-胃肠道粘膜淋巴组织抗原刺激后系统免疫的建立。讨论1 .人口腔疾病中血清和唾液抗体与细胞介导免疫的关系。- IgA缺乏的口腔表现。-讨论二。——结论。- IgA研讨会的印象、总结和提出的问题。-项目参与者。
Session A Developmental and Cellular Aspects Chairman: Lars A. Hanson.- The IgA System in Connection with Local and Systemic Immunity.- Origin, Distribution, and Differentiation of IgA-Producing Cells.- Cell Types Contributing to the Biosynthesis of sIgA.- DISCUSSION I.- Gut-Associated Lymphoblasts and Intestinal IgA Plasma Cells.- Bronchial Lymphoid Tissue.- The Origin of Monomeric and Polymeric Forms of IgA in Man.- Cytophilic Properties of IgA to Human Neutrophils.- DISCUSSION II.- Session B Structure, Biosynthesis, and Genetics Chairman: J. Claude Bennett.- Characteristics of SC-Ig Complexes Formed in vitro.- Association of S-IgA Subunits.- Modulation of the Assembly of Immunoglobulin Subunits.- DISCUSSION I - E. C. Franklin, Initial Discussant.- Mechanism of Immunoglobulin Polymer Assembly.- Assembly and Secretion of Immunoglobulin A.- Special Characteristics of the IgA2 Subclass.- Genetics and Evolution of Human Immunoglobulin A.- Physical-Chemical Characteristics of J Chains Obtained from IgM.- DISCUSSION II.- Session C Structure Chairman: Jiri Mestecky.- Isolation, Properties, and Structure of Human IgA Myeloma Globulins.- Amino Acid Sequence Studies of Human IgA Myeloma Proteins.- Structural Studies on a Human IgA1 Myeloma Protein with a Carboxy Terminal Deletion.- The Hinge Peptide of an IgA2m(2) Myeloma Protein.- The Carbohydrate Composition of Glycopeptides Isolated from IgA2 Immunoglobulin.- Mouse IgA Myeloma Proteins with Alpha Chain Deletions: A Comparison with Human Alpha Chains with Deletions.- DISCUSSION I.- Evidence for a Common Synthetic Origin for Secretory and Serum IgA.- Studies on the Primary Structure of Human Secretory Component.- Production of an Fc Fragment from Human Immunoglobulin A by an IgA-Specific Bacterial Protease.- Precipitin Cross-Reactions between Human and Animal J-Chains.- Disulfide Bridges of Human Immunoglobulins A1 and A2.- DISCUSSION II.- Session D Function Chairman: Frederick W. Kraus.- Implications of Secretory Immune System in Viral Infections.- The Role of the Secretory Immune System in Protection Against Agents Which Infect the Respiratory Tract.- The Role of Immunization in Controlling Antigen Uptake from the Small Intestine.- Lack of C3 Activation through Classical or Alternate Pathways by Human Secretory IgA Anti-Blood Group A Antibody.- DISCUSSION I.- Bacterial Adherence to Mucosal Surfaces and Its Inhibition by Secretory Antibodies.- Specificity of Antibodies to Streptococcus Mutans Significance in Inhibition of Adherence.- Secretory Antibodies in Milk of Swine Against Transmissible Gastroenteritis Virus.- Secretory IgA and Direct Killing of Shigella by Serum Components.- DISCUSSION II.- Session E Clinical Considerations Chairman: Max D. Cooper.- Current Knowledge on Alpha Chain Disease.- The Cellular Basis of IgA Deficiency in Humans.- Alpha Chain Determinants on the Membrane of Immunoglobulin Synthesizing Cells.- Secretory and Serum IgA in Children with Protein-Calorie Malnutrition.- Studies of Secretory Antibodies to E. Coli in Human Urine Compared to the Serum Antibody Content.- Secretory IgA: An Adolescent Coming of Age.- DISCUSSION I.- Types of Size Heterogeneity of IgA Molecules Isolated from Myeloma and Normal Human Serum.- Distribution of IgA Subclasses in Sera and Bone Marrow Plasma Cells of 21 Normal Individuals.- Selective IgA Deficiency and Chronic Obstructive Pulmonary Disease - A Family Study.- DISCUSSION II.- Session F The IgA Antibody Response Implications for Oral Health Chairman: Alexander R. Lawton.- The Induction and Characterization of Secretory IgA Antibodies.- Human Nasal Exocrine IgA Antibody: Formation and Some Activities.- The IgA Antibody-Forming Cell Response in the Rabbit Submandibular Gland Following Several Different Methods of Immunization.- The Establishment of Systemic Immunity Following Antigenic Stimulation of the Lymphoid Tissue of the Gastrointestinal Mucosa.- DISCUSSION I.- The Relationship between Serum and Salivary Antibodies and Cell Mediated Immunity in Oral Disease in Man.- Oral Manifestations of IgA Deficiency.- DISCUSSION II.- Conclusion.- Impressions, Summary, and Questions Raised by the IgA Symposium.- Program Participants.