Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
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DOI：
10.4103/0378-6323.57718
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发表时间：
2009-11-01
影响因子：
2.9
通讯作者：
Goyal, Ramesh K.
中科院分区：
文献类型：
--
作者：
Mehta, Timir Y.;Prajapati, Laxman M.;Goyal, Ramesh K.
Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
