How monocular deprivation shifts ocular dominance in visual cortex of young mice
How monocular deprivation shifts ocular dominance in visual cortex of young mice
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DOI：
10.1016/j.neuron.2004.12.003
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发表时间：
2004-12-16
期刊：
影响因子：
16.2
通讯作者：
Bear, MF
中科院分区：
文献类型：
--
作者：
Frenkel, MY;Bear, MF
我们使用一种慢性记录方法来记录幼鼠因暂时眼睑闭合所诱导的眼优势（OD）可塑性的动力学。我们发现单眼剥夺（MD）引发两种不同的改变：（1）快速的、剥夺诱导的反应抑制，以及（2）延迟的、剥夺所促成的、依赖经验的反应增强。为了深入了解改变视网膜活动如何触发这些皮质反应，我们比较了眼睑闭合导致的单眼剥夺（MD）与玻璃体内注射河豚毒素造成的单眼失活（MI）的影响。我们发现单眼失活（MI）未能诱导剥夺眼的反应抑制，但促进了正常眼驱动的反应增强。幼鼠中单眼失活（MI）的这些效应与成年鼠中单眼剥夺（MD）的效应非常相似。了解单眼失活（MI）和单眼剥夺（MD）如何不同地影响幼鼠视觉系统的活动，可能为关键期如何结束提供关键的见解。
We used a chronic recording method to document the kinetics of ocular dominance (OD) plasticity induced by temporary lid closure in young mice. We find that monocular deprivation (MD) induces two separate modifications: (1) rapid, deprivation-induced response depression and (2) delayed, deprivation-enabled, experience-dependent response potentiation. To gain insight into how altering retinal activity triggers these cortical responses, we compared the effects of MD by lid closure with monocular inactivation (MI) by intravitreal injection of tetrodotoxin. We find that MI fails to induce deprived-eye response depression but promotes potentiation of responses driven by the normal eye. These effects of MI in juvenile mice closely resemble the effects of MD in adult mice. Understanding how MI and MD differentially affect activity in the visual system of young mice may provide key insight into how the critical period ends.