The cognitive and anatomo-functional basis of reality distortion in schizophrenia: A view from memory event-related potentials
The cognitive and anatomo-functional basis of reality distortion in schizophrenia: A view from memory event-related potentials
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DOI：
10.1016/s0165-1781(03)00003-9
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发表时间：
2003-02
影响因子：
11.3
通讯作者：
F. Guillem;M. Bicu;T. Pampoulova;R. Hooper;D. Bloom;M. Wolf;J. Messier;René Désautels;C. Todorov;P. Lalonde;J. Debruille
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文献类型：
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作者：
F. Guillem;M. Bicu;T. Pampoulova;R. Hooper;D. Bloom;M. Wolf;J. Messier;René Désautels;C. Todorov;P. Lalonde;J. Debruille
本研究采用面孔再认记忆任务中的事件相关电位（ERPs），探讨精神分裂症患者现实扭曲的神经和认知相关性。之所以选择这项任务，是因为先前的研究表明，它提供了与特定认知过程和特定大脑区域功能相关的不同指标。在对照组和精神分裂症患者中记录了ERP，根据他们的现实扭曲评分（幻觉和妄想SAPS分量表）将他们分为高分者（RD+）和低分者（RD-）。结果表明，RD+在各种认知过程中存在异常。首先，RD+在干扰抑制和知识整合方面存在缺陷（降低了P2 a和N400效应）。在RD-中发现的类似损伤表明它们代表了疾病的基本特征。第二，RD+表现出不适当的刺激分类和上下文整合（较大的N300和额中枢效应）。第三，RD+表现出的晚期指数（P600效应）与对照组无差异，但大于RD-。该结果与RD+中记忆结合过程（不适当结合）的定性而非定量损伤一致。由于观察到的ERP异常的每一个代表与不同的脑功能障碍，进一步讨论的结果方面的各自贡献的顶叶，额叶和海马结构的现实扭曲症状。
This study investigated the neural and cognitive correlates of reality distortion in schizophrenia by using event-related potentials (ERPs) recorded in a recognition memory task for face. This task has been chosen because previous studies have shown that it provides distinct indices related to specific cognitive processes and to the functioning of specific brain regions. ERPs have been recorded in controls and schizophrenia patients separated into high scorers (RD+) and low-scorers (RD−) according to their Reality Distortion score (hallucination and delusion SAPS subscales). The results indicate that RD+ presents abnormalities on various cognitive processes. First, RD+ are deficient at interference inhibition and knowledge integration (reduced P2a and N400 effect). The similar impairments found in RD− suggest that they represent basic traits of the illness. Second, RD+ showed inappropriate stimulus categorization and contextual integration (larger N300 and fronto-central effect). Third, RD+ showed a late index (P600 effect) not different from controls, but larger than in RD−. This result is consistent with a qualitative, rather than quantitative, impairment of mnemonic binding processes (inappropriate binding) in RD+. Since each of the ERP abnormalities observed represents associated with distinct brain dysfunction, the results are further discussed in regard of the respective contribution of the parietal, frontal and hippocampal structures to reality distortion symptoms.