The synthesis of secretory IgA in the rabbit. I. Evidence for synthesis as an 11 S dimer.
The synthesis of secretory IgA in the rabbit. I. Evidence for synthesis as an 11 S dimer.
复制标题
兔子分泌型 IgA 的合成。
DOI：
10.4049/jimmunol.102.3.693
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发表时间：
1969
影响因子：
4.4
通讯作者：
R. Mage
中科院分区：
文献类型：
--
作者：
A. Lawton;R. Mage
定量沉淀素技术已表明来自 b 基因座控制的轻链同种异型杂合子的初乳 IgA 由具有一种等位基因类型或另一种等位基因类型但不是两者的分子组成。通过将 b4 和 b5 初乳 IgA 混合在 5 M 胍中并透析掉胍，获得包含两种特异性的分子。这些观察结果表明 11 S 初乳 IgA 在单细胞中合成为二聚体，而不是源自 7 S IgA。
Colostral IgA from rabbits heterozygous for light chain allotypic specificities controlled by the b locus has been shown by quantitative precipitin techniques to consist of molecules bearing one allelic type or the other but not both. Molecules containing both specificities were obtained by mixing b4 and b5 colostral IgA in 5 M guanidine and dialyzing away the guanidine. These observations indicate that 11 S colostral IgA is synthesized as a dimer in single cells and not derived from 7 S IgA.