Mistaken identity:: Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus
Mistaken identity:: Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus
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DOI：
10.1128/jcm.43.12.5996-5999.2005
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发表时间：
2005-12-01
影响因子：
9.4
通讯作者：
Marr, KA
中科院分区：
文献类型：
--
作者：
Balajee, SA;Gribskov, J;Marr, KA
由拟费氏奈氏菌引起的侵袭性真菌感染。W.彼得森无性型热变型曲霉Aspergillus thennomutatus（Paden）S. W. #21453;，非常罕见。表型上，N. pseudofischeri类似于烟曲霉菌，后者是免疫功能低下宿主中侵袭性曲霉病的主要病原。我们报告了三个临床分离的N。pseudofischeri，最初都被误认为是A.烟熏。通过对P-微管蛋白和小杆A基因的测序部分正确鉴定了所有三种分离株。3个菌株中只有1个产生了确认子实体，因此被分类为N。pseudofischeri;其他分离物不产生子囊，因此被鉴定为A.热致突变的所有三个分离株对伏立康唑的体外MIC均高于A。朋友Af 293.这份报告强调，丝状真菌的表型鉴定可能无法识别形态相似，但遗传不同，属Aspeiperidae部分Fumigati的成员。鉴于这些微生物在抗真菌药敏性方面的潜在差异，准确鉴定这些微生物可能具有临床意义。
Invasive fungal infections caused by Neosartorya pseudofischeri S. W. Peterson [anamorph Aspergillus thennomutatus (Paden) S. W. Peterson] are extremely rare. Phenotypically, the anamorphic state of N. pseudofischeri resembles Aspeigillus fumigatus, the predominant agent of invasive aspergillosis in immunocompromised hosts. We report the recovery of three clinical isolates of N. pseudofischeri, all initially misidentified by morphological characteristics as A. fumigatus. All three isolates were correctly identified by sequencing portions of the P-tubulin and the rodlet A genes. Only one of the three isolates produced the confirmatory fruiting bodies and was thus classified as N. pseudofischeri; the other isolates did not produce asci and were therefore identified as A. thermomutatus. All three isolates had higher MICs to voriconazole in vitro compared to A. Amigatus Af293. This report emphasizes that phenotypic identification of filamentous fungi may not identify morphologically similar, but genetically distinct, members of the genus Aspeigillus section Fumigati. Accurate identification of these organisms may be clinically meaningful, given their potential differences in antifungal susceptibilities.