Rate of blunt impact loading affects changes in retropatellar cartilage and underlying bone in the rabbit patella
Rate of blunt impact loading affects changes in retropatellar cartilage and underlying bone in the rabbit patella
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DOI：
10.1016/s0021-9290(02)00019-2
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发表时间：
2002-06-01
影响因子：
2.4
通讯作者：
Haut, RC
中科院分区：
文献类型：
--
作者：
Ewers, BJ;Jayaraman, VM;Haut, RC
我们的实验室建立了一个小型动物模型，使用巨型佛兰德兔来检查钝性撞击后关节组织的慢性降解性变化。从历史上看，我们观察到表面裂开和髌后弹性模数的下降。伴随着下面软骨下骨的增厚。以前的研究导致负荷侮辱在大约5毫秒的时间内达到峰值，而在车祸或剧烈运动期间发生的负荷会产生更长的上升时间。本研究的目的是使用我们建立的模型来检验钝冲击负荷率的影响。我们假设，在高(5ms至峰值)和低(50ms至峰值)加载实验中，撞击后膝关节后软骨的断裂和软化程度不会有显著差异。8只动物受到高负荷率的钝性冲击，10只动物在低负载率下受到相同的冲击载荷。另有8只动物作为对照种群。所有动物于撞击后12个月处死。这项研究对第一种假设产生了意想不到的结果。高负荷试验比低负荷试验产生更多的髌后软骨表面裂纹。然而，两种比率的软化程度相似，这支持第二种假设。此外，这项研究记录了在高负荷实验比低负荷试验下更多的膝后软骨下的骨增厚。目前的研究表明，慢性损伤机制可能高度依赖于冲击负荷的速度。这些数据可能会在高速“安全”设备的开发中变得极其重要，例如膝盖安全气囊，这些设备是在汽车碰撞中帮助定位未系安全带的乘客所需的。(C)2002年由爱思唯尔科学有限公司出版。
Our laboratory has developed a small animal model using Giant Flemish rabbits to examine chronic degradative changes in joint tissues following a blunt impact. Historically, we observe surface fissuring and decreases in the elastic modulus of retropatellar. with thickening of the underlying subchondral bone. Previous studies resulted in load insults that peaked in similar to 5 ms, cartilage along while loads that occur during automotive accidents or heavy exercise can produce longer rise times. The objective of the current study was to examine the influence of blunt impact loading rate using our established model. We hypothesized that the extent of fissuring and softening of retropatellar cartilage following impact would not be significantly different for a high (5 ms to peak) versus low (50 ms to peak) rate of loading experiment. Eight animals were impacted with a high rate of loading blunt impact, while ten animals were subjected to the same impact load at a low rate of loading. An additional eight animals served as a control population. All animals were sacrificed 12 months post-impact. The study yielded unexpected results for the first hypothesis. The high rate of loading experiments generated more surface Fissuring of the retropatellar cartilage than the low rate of loading experiments. However, the degree of softening was similar for the two rates, which supported the second hypothesis. Furthermore, the study documented more thickening of bone underlying retropatellar cartilage following the high versus the low rate of loading experiments. The current study suggested that chronic injury mechanisms may be highly dependent on the rate of impact loading. These data could become extremely relevant in the development of high-velocity "safety" devices, such as knee air bags, that are needed to help position an unbelted occupant in an automobile crash. (C) 2002 Published by Elsevier Science Ltd.