Mucosal responses evoked by stimulation of ganglion cell somas in the submucosal plexus of the guinea-pig ileum.
Mucosal responses evoked by stimulation of ganglion cell somas in the submucosal plexus of the guinea-pig ileum.
复制标题
刺激豚鼠回肠粘膜下神经丛中的神经节细胞体引起的粘膜反应。
DOI：
10.1113/jphysiol.1985.sp015730
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Zafirova,M
中科院分区：
文献类型：
--
作者：
Carey,HV;Cooke,HJ;Zafirova,M
在有和没有粘膜下丛的豚鼠回肠粘膜中比较了电场刺激和河豚毒素对粘膜分泌反应的影响。短路电流和跨壁电位差在神经节和无神经节组织中相似。去除粘膜下神经节后，总组织传导性更大。电场刺激引起神经节组织中短路电流的河豚毒素敏感性增加，而无神经节组织中几乎没有反应。神经节和aganglionated组织反应类似卡巴胆碱，血管活性肠多肽，蝎毒和丙氨酸。这些结果表明，豚鼠回肠的电场刺激引起短路电流的增加，其通过刺激神经节细胞体（其轴突投射到运输细胞和/或内分泌细胞）来反映氯化物分泌。肠内分泌细胞的直接电激活不是刺激诱发的分泌反应的因素。
The effects of electrical field stimulation and tetrodotoxin on the mucosal secretory response were compared in guinea‐pig ileal mucosa with and without the submucosal plexus. Short‐circuit currents and transmural electrical potential differences were similar in ganglionated and aganglionated tissues. Total tissue conductance was greater after removal of the submucosal ganglia. Electrical field stimulation evoked a tetrodotoxin‐sensitive increase in short‐circuit current in ganglionated tissues, and little or no response in aganglionated tissues. Both ganglionated and aganglionated tissues responded similarly to carbachol, vasoactive intestinal polypeptide, scorpion venom and alanine. These results suggest that electrical field stimulation of guinea‐pig ileum evokes an increase in short‐circuit current that reflects chloride secretion by exciting ganglion cell bodies whose axons project to the transporting cells and/or endocrine cells. Direct electrical activation of enteroendocrine cells is not a factor in the stimulus‐evoked secretory response.