Synthesis of [75Se]trimethylselenonium iodide from [75Se]selenocystine.
Synthesis of [75Se]trimethylselenonium iodide from [75Se]selenocystine.
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由[75Se]硒代胱氨酸合成[75Se]三甲基碘化硒。
DOI：
10.1016/0003-2697(84)90371-3
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发表时间：
1984
影响因子：
2.9
通讯作者：
Ganther,HE
中科院分区：
文献类型：
--
作者：
Foster,SJ;Ganther,HE
描述了从[75Se]硒代胱氨酸合成[75Se]三甲基碘化硒。用硼氢化物将起始化合物还原为[75Se]硒代半胱氨酸，并与碘甲烷反应形成[75Se]Se-甲基-硒代半胱氨酸，然后在甲酸溶液中用碘甲烷处理形成Se-二甲基-硒代半胱氨酸碘化硒。经过几天的时间，硒中间体自发消除，形成丙氨酸和二甲基硒化物，二甲基硒化物与碘甲烷反应，得到三甲基硒产品，产率超过 90%。
The synthesis of [75Se]trimethylselenonium iodide from [75Se]selenocystine is described. The starting compound is reduced to [75Se]selenocysteine with borohydride and reacted with methyl iodide to form [75Se]Se-methyl-selenocysteine, then treated with methyl iodide in formic acid solution to form Se-dimethyl-selenocysteine selenonium iodile. Over a period of days, the selenonium intermediate undergoes spontaneous elimination to form alanine and dimethyl selenide, which reacts with methyl iodide to give the trimethylselenonium product in over 90% yield.