An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms.
An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms.
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DOI：
10.1017/s0954579421001814
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发表时间：
2022-05
影响因子：
3.3
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Chahal, Rajpreet;Miller, Jonas G.;Yuan, Justin P.;Buthmann, Jessica L.;Gotlib, Ian H.
逆境的不同维度可能通过不同的神经生物学机制影响心理健康，尽管目前的支持证据主要包括威胁或剥夺与额叶边缘系统回路之间的横截面关联。在这项探索性的三波纵向研究中，年龄跨度为9-19岁，我们研究了不可预测性，威胁和剥夺的经验与涉及精神病理学的三个大脑网络内部和之间的功能连接发展之间的关联：显著性（SAL）、默认模式（DMN）和额顶（FPN）网络，并测试网络轨迹是否调节逆境和内化症状变化之间的关联。平均而言，连接性随着年龄的增长而下降;这些变化因逆境的程度而异。而家庭层面的剥夺与较低的初始水平和更稳定的大多数网络，不可预测性与稳定性只在SAL连接，和威胁与稳定性FPN和DMN-SAL连接。在暴露于更高水平的任何逆境的青年中，较低的初始水平和连接的更稳定性与内化症状的较小增加有关。我们的研究结果表明，而剥夺与广泛的神经发育差异的认知和情绪处理网络，不可预测性是有选择性地与显着性检测电路。具有更宽发育窗口的研究应该检查这些神经发育改变是否是适应性的或用于维持内化症状。
Different dimensions of adversity may affect mental health through distinct neurobiological mechanisms, though current supporting evidence consists largely of cross-sectional associations between threat or deprivation and fronto-limbic circuitry. In this exploratory three-wave longitudinal study spanning ages 9–19 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms.
影响因子：
4.6
作者：
Sylvester CM;Whalen DJ;Belden AC;Sanchez SL;Luby JL;Barch DM
通讯作者：
Barch DM