Blurring the Lines between Host and Guest: A Chimeric Receptor Derived from Cucurbituril and Triptycene
Blurring the Lines between Host and Guest: A Chimeric Receptor Derived from Cucurbituril and Triptycene
复制标题
DOI：
10.1002/anie.201803132
复制
发表时间：
2018-07-02
影响因子：
16.6
通讯作者：
Isaacs, Lyle
中科院分区：
文献类型：
--
作者：
Lu, Xiaoyong;Samanta, Soumen K.;Isaacs, Lyle
我们报告了葫芦脲-三蝶烯嵌合受体的合成和 X 射线晶体结构 (1)。宿主 1 与 CB[6]-CB[8] 的典型客体结合，但也与较大的客体结合，例如蓝盒 (20) 和藤田方形 (22)。有趣的是，1.20 和 1.22 复合体的几何形状模糊了主机和客体之间的界限，因为这两个组件在每个复合体中都扮演着两种角色。 1 的荧光输出通过与吡啶鎓衍生客体形成复合物而被完全猝灭。
We report the synthesis and X-ray crystal structure of a cucurbituril-triptycene chimeric receptor (1). Host 1 binds to guests typical of CB[6]-CB[8], but also binds to larger guests such as blue box (20) and the Fujita square (22). Intriguingly, the geometries of the 1.20 and 1.22 complexes blur the lines between host and guest in that both components fulfill both roles within each complex. The fluorescence output of 1 is fully quenched by the formation of complexes with pyridinium-derived guests.