Preconceptional, prenatal and postnatal exposure to outdoor and indoor environmental factors on allergic diseases/symptoms in preschool children
Preconceptional, prenatal and postnatal exposure to outdoor and indoor environmental factors on allergic diseases/symptoms in preschool children
复制标题
孕前、产前和产后接触室外和室内环境因素对学龄前儿童过敏性疾病/症状的影响
DOI：
10.1016/j.chemosphere.2016.03.032
复制
发表时间：
2016-06-01
期刊：
影响因子：
8.8
通讯作者：
Yuan, Hong
中科院分区：
文献类型：
--
作者：
Deng, Qihong;Lu, Chan;Yuan, Hong
背景：环境因素已被发现与变态反应性疾病有关，但哪种环境因素在哪个暴露窗期间引起何种变态反应性疾病尚不清楚。目的：我们调查了中国2598名儿童孕前、产前和产后暴露于一些主要的室内外环境因素与变态反应性疾病/症状的关系。方法：采用问卷调查的方法，调查儿童一生中变态反应性疾病的发病率、过敏症状的现患率以及对室内新家具/重新装修和霉变/潮湿的暴露。通过在空气质量监测站测量的浓度来估计暴露于室外空气污染物的量。用多元Logistic回归模型分析室外空气污染物与室内环境因素与过敏性疾病(哮喘、过敏性鼻炎、湿疹)和症状(喘息、夜间咳嗽、鼻炎样)的关系。结果：产前、出生后暴露于室外工业和交通空气污染物与儿童哮喘的风险增加显著相关，与过敏性鼻炎和湿疹呈正相关。然而，我们不能区分室外空气污染物和暴露窗的影响，因为它们之间有很高的相关性。新家具在出生后暴露期间与湿疹和过敏性鼻炎有关，但在产前暴露期间重新装修与哮喘和湿疹有关。室内可见霉菌/湿渍对出生前暴露的湿疹和出生后暴露的哮喘分别有显著意义，但窗户凝结对所有儿童过敏性疾病在产前和出生后暴露都有显著意义。儿童过敏症状仅与室内环境因素暴露有关。结论：室外空气污染物与室内环境因素与儿童过敏性疾病/症状的关系不同，且与暴露时间有关。(C)2016爱思唯尔有限公司。保留所有权利。
Background: Environmental factors have been found to be associated with allergic diseases, but it is unclear which environmental factor during which exposure window causes what kind of allergic diseases.Objectives: We investigated association between exposure to some predominant outdoor and indoor environmental factors during preconceptional, prenatal, and postnatal periods and allergic diseases/symptoms in 2598 children in China.Methods: Children's lifetime incidence of allergic diseases and current prevalence of allergic symptoms and exposure to indoor new furniture/redecoration and mold/dampness was surveyed by a questionnaire. Exposure to outdoor air pollutants was estimated by the concentrations measured at air quality monitoring stations. Multiple logistic regression model was used to evaluate the associations between outdoor air pollutants and indoor environmental factors and allergic diseases (asthma, allergic rhinitis, and eczema) and symptoms (wheezing, night cough, and rhinitis-like).Results: We found that preconceptional, prenatal, and postnatal exposure to outdoor industrial and traffic air pollutants were significantly associated with increase in the risk of childhood asthma, and also positively associated with allergic rhinitis and eczema. However, we cannot distinguish the effect of outdoor air pollutants and exposure windows because of their high correlations. New furniture was associated with eczema and allergic rhinitis during postnatal exposure, but redecoration associated with asthma and eczema during prenatal exposure. Indoor visible mold/damp stains was significant for eczema during prenatal exposure and asthma during postnatal exposure respectively, but window condensation was significant for all childhood allergic diseases during both prenatal and postnatal exposures. Allergic symptoms in children were found to be associated with exposure to indoor factors only.Conclusions: Associations between outdoor air pollutants and indoor environmental factors and childhood allergic diseases/symptoms were divergent and related to the timing of exposure. (C) 2016 Elsevier Ltd. All rights reserved.