The role of the hippocampus in object recognition in rats: Examination of the influence of task parameters and lesion size
The role of the hippocampus in object recognition in rats: Examination of the influence of task parameters and lesion size
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DOI：
10.1016/j.bbr.2005.09.005
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发表时间：
2006-02-15
影响因子：
2.7
通讯作者：
Wood, ER
中科院分区：
文献类型：
--
作者：
Ainge, JA;Heron-Maxwell, C;Wood, ER
研究了大鼠海马区病变对物体识别记忆的影响，得出了相互矛盾的结果。本研究调查了方法差异和病变大小可能是如何导致这些差异的。在实验1中，我们比较了完全、部分(隔区)和假海马区损伤的大鼠在自发的物体识别任务中的表现，使用了先前报道的导致大海马区损伤后出现缺陷的方案[10]。有完整和部分海马区损伤的大鼠没有受到损害，这表明海马区不是物体识别记忆所必需的。然而，部分损伤的大鼠表现出相对较差的表现，这增加了地板效应掩盖了这一组石油不足的可能性。在实验2中，我们使用了第二种自发物体识别方案，类似于其他两项研究所使用的方案，这两项研究报告了海马损伤后的缺陷[6.26]。海马区完全受损的大鼠显著受损，而部分受损的大鼠则未受损。然而，完全性病变组在样本阶段表现出较少的物体探索。因此，实验2中的明显再认记忆缺陷可能归因于差异编码。总而言之，这些发现表明，完整的自发物体识别记忆并不需要海马体。这些发现表明，样本阶段的物体探索水平可能是一个关键问题，并增加了以前关于物体识别缺陷的报道可能是由于物体探索的差异而不是物体识别本身的缺陷。(C)2005 Elsevier B.V.保留所有权利。
Studies examining the effects of hippocampal lesions oil object recognition memory in rats have produced conflicting results. The present Study investigated how methodological differences and lesion size may have contributed to these discrepancies. In Experiment 1 we compared rats with complete, partial (septal) and sham hippocampal lesions oil a spontaneous object recognition task, using a protocol previously reported to result in deficits following large hippocampal lesions [10]. Rats with complete and partial hippocampal lesions were unimpaired, suggesting the hippocampus is not required for object recognition memory. However, rats with partial lesions showed relatively poor performance raising the possibility that floor effects masked a deficit oil this group. In Experiment 2 we used a second spontaneous object recognition protocol similar to that used by the two other studies that have reported deficits following hippocampal lesions [6.26]. Rats with complete hippocampal lesions were significantly impaired, whereas rats with partial lesions were unimpaired. However, the complete lesion group showed less object exploration during the sample phase. Thus, the apparent recognition memory deficit ill Experiment 2 may be attributable to differential encoding. Together, these findings suggest that the hippocampus is not required for intact spontaneous object recognition memory. These findings suggest that levels of object exploration during the sample phase may be a critical issue, and raise the possibility that previous reports of object recognition deficits may be due to differences in object exploration rather than deficits in object recognition per se. (c) 2005 Elsevier B.V. All rights reserved.