EFFECT OF DIETARY FISH-OIL SUPPLEMENTATION ON FEVER AND CYTOKINE PRODUCTION IN HUMAN VOLUNTEERS
EFFECT OF DIETARY FISH-OIL SUPPLEMENTATION ON FEVER AND CYTOKINE PRODUCTION IN HUMAN VOLUNTEERS
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DOI：
10.1016/0261-5614(93)90027-2
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发表时间：
1993-12-01
影响因子：
6.3
通讯作者：
ROTHWELL, NJ
中科院分区：
文献类型：
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作者：
COOPER, AL;GIBBONS, L;ROTHWELL, NJ
在人类志愿者中研究了膳食鱼油补充剂对肌内注射伤寒疫苗的急性期反应以及体外细胞因子产生的影响。一半受试者每天补充 4.5 克鱼油，持续 6-8 周。在未补充的受试者中注射伤寒疫苗会导致白细胞计数、静息心率、代谢率、耗氧量和口腔温度增加。补充鱼油可抑制心动过速，并减弱伤寒疫苗接种后口腔温度和代谢率的最大增加。然而，由于注射盐水的受试者的反应同样减弱，对后面这些结果的解释变得复杂。然而，补充鱼油可抑制全血中白细胞介素 1 和白细胞介素 6 的体外产生。肿瘤坏死因子a没有显着改变。因此，补充鱼油可能提供一种非药物方法来减弱与损伤和感染相关的几种反应，这可能与减少细胞因子（IL-1 和 IL-6）的产生有关。
The effect of dietary fish oil supplementation on acute phase responses to intramuscular injection of typhoid vaccine, and in vitro cytokine production, was investigated in human volunteers. Half of the subjects supplemented their normal diet with 4.5 g/day of fish oil for 6-8 weeks. Injection of typhoid vaccine in unsupplemented subjects caused an increase in white cell count, resting heart rate, metabolic rate, oxygen consumption, and oral temperature. Fish oil supplementation inhibited the tachycardia and attenuated the maximal increases in oral temperature and metabolic rate following typhoid vaccine. However, interpretation of these latter results were complicated by similarly attenuated responses in saline-injected subjects. The in vitro production of interleukin-1 and interleukin-6 from whole blood was suppressed by fish oil supplementation, however, production. of tumor necrosis factor a was not significantly altered. Fish oil supplementation may therefore provide a non-pharmacological approach of attenuating several of the responses associated with injury and infection and this may be related to reduced cytokine (IL-1 and IL-6) production.